Overestimation of genetic risks owing to small sample sizes in cardiovascular studies
Morgan T, Coffey C, Krumholz H. Overestimation of genetic risks owing to small sample sizes in cardiovascular studies. Clinical Genetics 2003, 64: 7-17. PMID: 12791034, DOI: 10.1034/j.1399-0004.2003.00088.x.Peer-Reviewed Original ResearchConceptsACE DMyocardial infarctionRisk factorsPublication biasEnzyme deletion polymorphismStudies of angiotensinThrombotic risk factorsGenetic risk factorsPotential publication biasCardiovascular outcomesPlA2 polymorphismOdds ratioEgger's testFunnel plotSystematic reviewCardiovascular studiesRelevant outcomesOverall riskSmall sample sizeGenetic riskSample sizeDeletion polymorphismUnderpowered studiesInfarctionPLA2