2018
Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload?
Goldwater DS, Dharmarajan K, McEwan BS, Krumholz HM. Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? Journal Of Hospital Medicine 2018, 13 PMID: 29813141, DOI: 10.12788/jhm.2986.Peer-Reviewed Original ResearchConceptsPosthospital syndromeAllostatic overloadAutonomic nervous systemMultiple organ systemsHospital dischargeInflammatory markersAdverse eventsHospital readmissionAdrenal axisAdverse outcomesPlausible etiologyPathophysiologic consequencesElevated riskNervous systemNarrative reviewOrgan systemsEnhanced vulnerabilityElevated levelsHospital environmentTraditional hospital environmentSyndromeMaladaptive statesOverloadOutcomesPossible mechanism
2001
Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension
Abramson J, Berger A, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension. JAMA Internal Medicine 2001, 161: 1725-1730. PMID: 11485505, DOI: 10.1001/archinte.161.14.1725.Peer-Reviewed Original ResearchConceptsHeart failureSystolic hypertensionMyocardial infarctionDepressed personsOlder personsCox proportional hazards regressionEpidemiological Studies Depression ScaleIsolated systolic hypertensionIncident heart failureCoronary heart diseaseProportional hazards regressionBlood pressureElectrocardiographic abnormalitiesHazards regressionElderly ProgramCholesterol levelsHeart diseaseRisk factorsNondepressed personsDepression ScaleAdditional adjustmentElevated riskHigh riskTreatment groupsHypertension