2016
Life Expectancy after Myocardial Infarction, According to Hospital Performance
Bucholz EM, Butala NM, Ma S, Normand ST, Krumholz HM. Life Expectancy after Myocardial Infarction, According to Hospital Performance. New England Journal Of Medicine 2016, 375: 1332-1342. PMID: 27705249, PMCID: PMC5118048, DOI: 10.1056/nejmoa1513223.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized mortality ratesMyocardial infarctionLife expectancyMortality rateHospital performanceCooperative Cardiovascular ProjectProportional hazards modelLong-term survivalCase-mix severityLonger life expectancySurvival benefitInfarctionMedicare beneficiariesPatientsHospital case mixCase mixHospitalSurvival curvesQuintileStudy sampleSignificant differencesEarly survivalExpectancySurvivalLife Years Gained From Smoking-Cessation Counseling After Myocardial Infarction
Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Life Years Gained From Smoking-Cessation Counseling After Myocardial Infarction. American Journal Of Preventive Medicine 2016, 52: 38-46. PMID: 27692757, PMCID: PMC5459385, DOI: 10.1016/j.amepre.2016.08.013.Peer-Reviewed Original ResearchConceptsSmoking cessation counselingAcute myocardial infarctionLong-term survival benefitLife yearsSurvival benefitMyocardial infarctionLife expectancyLower short-term mortalityHigher crude mortalityLong-term mortalityProspective cohort studyShort-term mortalityCooperative Cardiovascular ProjectProportional hazards modelLonger life expectancyCohort studyElderly patientsElderly smokersOlder smokersCrude mortalitySurvival differencesHospital characteristicsSmokersHazards modelLower mortalityAssociation of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries
Bucholz EM, Butala NM, Normand SL, Wang Y, Krumholz HM. Association of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries. Journal Of The American College Of Cardiology 2016, 67: 2378-2391. PMID: 27199062, PMCID: PMC5097252, DOI: 10.1016/j.jacc.2016.03.507.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAspirinFemaleFollow-Up StudiesGuideline AdherenceHospitalizationHumansLife ExpectancyMaleMedicareMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPractice Guidelines as TopicThrombolytic TherapyTime-to-TreatmentUnited StatesConceptsAcute myocardial infarctionPrimary percutaneous coronary interventionGuideline-based therapyYears of lifeAdmission therapyLife expectancyMyocardial infarctionMedicare beneficiariesCox proportional hazards regressionAcute reperfusion therapyLate survival benefitReceipt of aspirinPercutaneous coronary interventionLong-term outcomesProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesDose-response relationshipAssociation of GuidelineShort life expectancyLonger life expectancyReperfusion therapyCoronary interventionD2B timeElderly patientsUnderweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries
Bucholz EM, Krumholz HA, Krumholz HM. Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries. PLOS Medicine 2016, 13: e1001998. PMID: 27093615, PMCID: PMC4836735, DOI: 10.1371/journal.pmed.1001998.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBody Mass IndexCachexiaComorbidityFemaleFrail ElderlyGeriatric AssessmentHospital MortalityHumansInsurance BenefitsKaplan-Meier EstimateMaleMedicareMyocardial InfarctionNutrition AssessmentNutritional StatusPrevalencePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThinnessTime FactorsUnited StatesConceptsLower body mass indexNormal weight patientsBody mass indexAcute myocardial infarctionUnderweight patientsWeight patientsSubset of patientsHigh riskFrailty measuresLaboratory markersMyocardial infarctionMedicare beneficiariesNutritional statusCox proportional hazards regressionUnderweight body mass indexMarkers of cachexiaLong-term mortalityProspective cohort studyCohort-based studyMeasures of frailtyProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesImportant risk factorSignificant chronic illness
2015
Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined
Bucholz EM, Beckman AL, Krumholz HA, Krumholz HM, conducted. B. Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined. American Heart Journal 2015, 172: 173-181. PMID: 26856230, PMCID: PMC5097250, DOI: 10.1016/j.ahj.2015.10.024.Peer-Reviewed Original ResearchConceptsNormal weight patientsAcute myocardial infarctionBody mass indexHigher body mass indexLong-term survivalObese patientsOverweight patientsObesity paradoxExcess weightMyocardial infarctionLife expectancyTime of AMIHigher crude mortalityTime pointsShort-term mortalityCooperative Cardiovascular ProjectMedical record studyProportional hazards modelYears of ageMorbid obesityOlder patientsSurvival benefitYounger patientsCrude mortalityBMI groupsSmoking status and life expectancy after acute myocardial infarction in the elderly
Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Smoking status and life expectancy after acute myocardial infarction in the elderly. Heart 2015, 102: 133. PMID: 26596792, PMCID: PMC5459390, DOI: 10.1136/heartjnl-2015-308263.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCurrent smokersYears of lifeLife expectancyMyocardial infarctionLower short-term mortalityHigher long-term mortalityLower crude mortalityLong-term mortalityBurden of smokingShort-term mortalityCooperative Cardiovascular ProjectElderly Medicare patientsAge-specific associationsMedical record studyCurrent smokingCrude mortalityPatient characteristicsSmoking statusCessation effortsMedicare patientsLong-term effectsSmokingSmokersLower life expectancyLife Expectancy and Years of Potential Life Lost After Acute Myocardial Infarction by Sex and Race A Cohort-Based Study of Medicare Beneficiaries
Bucholz EM, Normand SL, Wang Y, Ma S, Lin H, Krumholz HM. Life Expectancy and Years of Potential Life Lost After Acute Myocardial Infarction by Sex and Race A Cohort-Based Study of Medicare Beneficiaries. Journal Of The American College Of Cardiology 2015, 66: 645-655. PMID: 26248991, PMCID: PMC5459400, DOI: 10.1016/j.jacc.2015.06.022.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite patientsBlack patientsLife expectancyMyocardial infarctionMedicare beneficiariesCox proportional hazards regressionPotential lifeProspective cohort studyCohort-based studyProportional hazards regressionCooperative Cardiovascular ProjectBurden of diseaseLong-term survivalCohort studyClinical presentationHazards regressionBlack raceSurvival advantageGeneral populationPatientsAverage ageRace differencesLife expectancy estimatesYPLL
2008
Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction
Parikh CR, Coca SG, Wang Y, Masoudi FA, Krumholz HM. Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction. JAMA Internal Medicine 2008, 168: 987-995. PMID: 18474763, DOI: 10.1001/archinte.168.9.987.Peer-Reviewed Original ResearchConceptsSevere acute kidney injuryAcute kidney injuryAcute myocardial infarctionMild acute kidney injuryModerate acute kidney injuryKidney injuryLong-term riskMyocardial infarctionSeverity of AKIAdjusted hazard ratioLong-term mortalitySerum creatinine levelsLong-term prognosisCooperative Cardiovascular ProjectElderly Medicare patientsHigh-risk groupAssociation of severityHospital mortalityHospital survivorsCause mortalityCardiovascular mortalityCreatinine levelsHazard ratioInpatient mortalityCommon complication
2007
Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction
Smith GL, Masoudi FA, Shlipak MG, Krumholz HM, Parikh CR. Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction. Journal Of The American Society Of Nephrology 2007, 19: 141-150. PMID: 18003773, PMCID: PMC2391037, DOI: 10.1681/asn.2007050554.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRenal functionRenal impairmentCreatinine clearanceMortality riskMyocardial infarctionCockcroft-Gault creatinine clearanceLong-term mortality riskMild renal impairmentSevere renal impairmentNormal renal functionCohort of patientsCooperative Cardiovascular ProjectPatient ageSystolic functionHospitalized patientsPrognostic importanceRisk factorsPatientsMortalityImpairmentClearanceGFRInfarctionRisk
2006
Gender Differences in Treatment of Heart Failure and Acute Myocardial Infarction
Gold LD, Krumholz HM. Gender Differences in Treatment of Heart Failure and Acute Myocardial Infarction. Cardiology In Review 2006, 14: 180-186. PMID: 16788330, DOI: 10.1097/01.crd.0000194093.53005.f0.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureMyocardial infarctionCoronary artery bypass graft surgeryNational Heart Failure ProjectArtery bypass graft surgeryLeft ventricular ejection fractionShort-term mortality rateEnzyme inhibitor prescriptionHeart Failure ProjectBypass graft surgeryPercutaneous coronary interventionVentricular ejection fractionCooperative Cardiovascular ProjectRisk of mortalityQuality of carePoor quality careGraft surgeryInhibitor prescriptionCoronary interventionFibrinolytic therapyReadmission ratesCardiac catheterizationEjection fractionACE inhibitorsQuality of Care for Acute Myocardial Infarction in Elderly Patients with Alcohol‐Related Diagnoses
Fiellin DA, O'Connor PG, Wang Y, Radford MJ, Krumholz HM. Quality of Care for Acute Myocardial Infarction in Elderly Patients with Alcohol‐Related Diagnoses. Alcohol Clinical And Experimental Research 2006, 30: 70-75. PMID: 16433733, DOI: 10.1111/j.1530-0277.2006.00001.x.Peer-Reviewed Original ResearchConceptsAlcohol-related diagnosesAcute myocardial infarctionMyocardial infarctionElderly patientsEligible patientsCare measuresRetrospective cohort analysisPrincipal discharge diagnosisTime of dischargeCooperative Cardiovascular ProjectAcute care hospitalsMedical record dataQuality of careBaseline characteristicsCare hospitalPrimary outcomeDischarge diagnosisCohort analysisAlcohol abuseMedicare beneficiariesInfarctionPatientsElderly adultsAlcohol dependenceQuality care
2005
The generalizability of observational data to elderly patients was dependent on the research question in a systematic review
Gross CP, Garg PP, Krumholz HM. The generalizability of observational data to elderly patients was dependent on the research question in a systematic review. Journal Of Clinical Epidemiology 2005, 58: 130-137. PMID: 15680745, DOI: 10.1016/j.jclinepi.2004.10.001.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectIntracranial hemorrhageSystematic reviewBeta-blocker useElderly patientsAngiography useCommunity patientsAtrial fibrillationRisk factorsObservational studyOutcome measuresRCT dataPresentation delayGlobal UtilizationT-PAPatientsSimilar predictorsTreatment variationStudy questionsCCP dataGUSTOHemorrhageReviewFibrillationAbsolute rate
2003
Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study
Krumholz HM, Gross CP, Peterson ED, Barron HV, Radford MJ, Parsons LS, Every NR. Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study. American Heart Journal 2003, 146: 839-847. PMID: 14597933, DOI: 10.1016/s0002-8703(03)00408-3.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectRandomized trialsExclusion criteriaEligibility criteriaMortality rateClinical practiceKillip class III/IVClass III/IVOccluded Coronary Arteries (GUSTO-I) trialCoronary Arteries trialHospital mortality rateMyocardial infarction careTrial eligibility criteriaHigh mortality rateRetrospective registryBaseline characteristicsClinical characteristicsElderly patientsOlder patientsCCP patientsClinical presentationClinical eventsMyocardial infarctionHealthy cohortHospital characteristicsEffects of age on the quality of care provided to older patients with acute myocardial infarction
Rathore SS, Mehta RH, Wang Y, Radford MJ, Krumholz HM. Effects of age on the quality of care provided to older patients with acute myocardial infarction. The American Journal Of Medicine 2003, 114: 307-315. PMID: 12681459, DOI: 10.1016/s0002-9343(02)01531-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAttitude of Health PersonnelCohort StudiesCombined Modality TherapyCoronary Care UnitsCritical CareDrug UtilizationFemaleGuideline AdherenceHealth Services AccessibilityHealth Services for the AgedHumansLogistic ModelsMaleMedicareMyocardial InfarctionOdds RatioPractice Patterns, Physicians'Quality of Health CareRisk AssessmentSurvival AnalysisThrombolytic TherapyUnited StatesConceptsAcute reperfusion therapyAcute myocardial infarctionMyocardial infarctionReperfusion therapyEffect of ageElderly patientsOlder patientsAge-associated variationsGuideline-recommended medical therapyAngiotensin-converting enzyme inhibitorGuideline-indicated therapiesPrescription of aspirinUse of aspirinCooperative Cardiovascular ProjectUse of therapiesQuality of careAcute reperfusionTreatment contraindicationsMedical therapyComorbid conditionsACE inhibitorsMedicare patientsHospital effectsPatientsEnzyme inhibitors
2002
Acute myocardial infarction in the elderly with diabetes
Chyun D, Vaccarino V, Murillo J, Young LH, Krumholz HM. Acute myocardial infarction in the elderly with diabetes. Heart & Lung 2002, 31: 327-339. PMID: 12487011, DOI: 10.1067/mhl.2002.126049.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDiabetes mellitusMyocardial infarctionHeart failureComorbid conditionsMortality rateNon-Q-wave myocardial infarctionHistory of DMInsulin-treated diabetes mellitusRetrospective medical record reviewHigher body mass indexAcute MI settingPoor functional statusBlood pressure managementMedical record reviewSpecific comorbid conditionsSecondary preventive interventionsBody mass indexShort-term mortalityCooperative Cardiovascular ProjectEntire Medicare populationShort-term riskAggressive lipidDM statusChest painEvaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data
Krumholz HM, Rathore SS, Chen J, Wang Y, Radford MJ. Evaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data. JAMA 2002, 287: 1277-1287. PMID: 11886319, DOI: 10.1001/jama.287.10.1277.Peer-Reviewed Original ResearchConceptsProcess of careMortality rateHospital ratingEnzyme inhibitorsUS acute care hospitalsSystematic medical record reviewIndividual hospitalsStudy periodAcute myocardial infarction mortalityAcute reperfusion therapyReperfusion therapy ratesMedical record reviewService beneficiaries 65 yearsCooperative Cardiovascular ProjectBeneficiaries 65 yearsAcute care hospitalsMyocardial infarction mortalityHealth care report cardsQuality of careCare report cardsHospital performanceReperfusion therapyTherapy ratesCare hospitalRecord reviewNonsteroidal antiinflammatory drugs after acute myocardial infarction
Ko D, Wang Y, Berger AK, Radford MJ, Krumholz HM. Nonsteroidal antiinflammatory drugs after acute myocardial infarction. American Heart Journal 2002, 143: 475-481. PMID: 11868054, DOI: 10.1067/mhj.2002.121270.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNonsteroidal antiinflammatory drugsNSAID therapyMyocardial infarctionAddition of aspirinMortality rateAspirin therapyElderly patientsAntiinflammatory drugsMedicare beneficiariesUse of NSAIDsRetrospective medical record reviewAdditional survival benefitMedical record reviewCooperative Cardiovascular ProjectElderly Medicare beneficiariesHospital dischargeOlder patientsSurvival benefitRecord reviewClinical informationInfarctionAspirinPatientsMedications
2001
Sex Differences in Cardiac Catheterization: The Role of Physician Gender
Rathore SS, Chen J, Wang Y, Radford MJ, Vaccarino V, Krumholz HM. Sex Differences in Cardiac Catheterization: The Role of Physician Gender. JAMA 2001, 286: 2849-2856. PMID: 11735761, DOI: 10.1001/jama.286.22.2849.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterizationMale physiciansFemale physiciansPatient sexPhysician sexCardiac proceduresRetrospective medical record reviewSex differencesUS acute care hospitalsProcedure useCardiac procedure useDay of admissionMedical record reviewCooperative Cardiovascular ProjectAcute care hospitalsCare hospitalMultivariable analysisRecord reviewPotential confoundersMyocardial infarctionPhysician genderCatheterizationMAIN OUTCOMEClinical careThe association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project
Barron H, Harr S, Radford M, Wang Y, Krumholz H. The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project. Journal Of The American College Of Cardiology 2001, 38: 1654-1661. PMID: 11704377, DOI: 10.1016/s0735-1097(01)01613-8.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite blood cell countBlood cell countWBC countWhite blood cellsYears of ageIndependent predictorsCell countDevelopment of AMIAcute myocardial infarction mortalityHospital clinical eventsLong-term mortalityRisk-stratify patientsCoronary artery diseaseCooperative Cardiovascular Project databaseStrong independent predictorCooperative Cardiovascular ProjectMyocardial infarction mortalityImportant clinical implicationsHospital mortalityArtery diseaseHospital eventsClinical eventsHighest quintileLowest quintilePredicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
Krumholz H, Chen J, Chen Y, Wang Y, Radford M. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. Journal Of The American College Of Cardiology 2001, 38: 453-459. PMID: 11499737, DOI: 10.1016/s0735-1097(01)01395-x.Peer-Reviewed Original ResearchConceptsOne-year mortalityAcute myocardial infarctionMyocardial infarctionPeripheral vascular diseaseCohort of patientsBody mass indexCooperative Cardiovascular ProjectRisk of mortalityDeath one yearPopulation-based sampleSimple risk modelRenal dysfunctionVentricular dysfunctionElderly patientsOlder patientsUrinary incontinenceHeart failureMass indexAcute carePrognostic importanceMean ageVascular diseaseMedical recordsRisk groupsOlder survivors