2024
Barriers to Optimal Clinician Guideline Adherence in Management of Markedly Elevated Blood Pressure
Lu Y, Arowojolu O, Qiu X, Liu Y, Curry L, Krumholz H. Barriers to Optimal Clinician Guideline Adherence in Management of Markedly Elevated Blood Pressure. JAMA Network Open 2024, 7: e2426135. PMID: 39106065, PMCID: PMC11304113, DOI: 10.1001/jamanetworkopen.2024.26135.Peer-Reviewed Original ResearchConceptsBarriers to guideline adherenceElectronic health recordsGuideline adherenceClinician adherenceEHR dataElevated blood pressureHypertension managementAnalysis of EHR dataYale New Haven Health SystemSevere hypertensionClinical practice guidelinesAdherence scenariosQualitative content analysisPublic health challengeThematic saturationHealth recordsHealth systemBlood pressureThematic analysisTargeted interventionsManagement of severe hypertensionQualitative studyHealth challengesPractice guidelinesPatient outcomes
2021
Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries
Wheelock KM, Ross JS, Murugiah K, Lin Z, Krumholz HM, Khera R. Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries. JAMA Network Open 2021, 4: e2137288. PMID: 34870678, PMCID: PMC8649845, DOI: 10.1001/jamanetworkopen.2021.37288.Peer-Reviewed Original ResearchConceptsDOAC useAnticoagulant prescriptionOral anticoagulantsUS cliniciansMedicare beneficiariesNational clinical practice guidelinesElevated bleeding riskOral anticoagulant prescriptionsRetrospective cohort studyDirect oral anticoagulantsClinical practice guidelinesUS Medicare beneficiariesInternal medicine physiciansNumber of cliniciansAnticoagulant prescribingDOAC prescriptionsUnique cliniciansBleeding riskCohort studyAnticoagulant strategiesPrescription claimsPractice guidelinesMAIN OUTCOMEMost indicationsMedicare population
2017
ACC/AHA Special Report
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL, Castillo G, Heil SK, Stephens J, Jacobson Vann J. ACC/AHA Special Report. Circulation 2017, 135: e122-e137. PMID: 28126839, DOI: 10.1161/cir.0000000000000481.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesImplementation interventionsSystematic reviewLow baseline adherenceOverweight/obesityMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeExclusion criteriaIndependent reviewersCare outcomesClinician skepticismHigher ageACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL. ACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal Of The American College Of Cardiology 2017, 69: 1076-1092. PMID: 28132746, DOI: 10.1016/j.jacc.2016.11.004.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesSystematic reviewImplementation interventionsCardiology/American Heart Association Task ForceAmerican Heart Association Task ForceLow baseline adherenceOverweight/obesityGuideline implementation strategiesMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeAmerican CollegeExclusion criteria
2016
2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST‐elevation myocardial Infarction: An update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST‐elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
Cardiology E, COMMITTEE P, Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, COMMITTEE S, O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby L, Ornato JP, Ou N, Radford MJ, Tamis‐Holland J, Tommaso CL, Tracy CM, Woo Y, Zhao DX, MEMBERS A, Halperin JL, Levine GN, Anderson JL, Albert NM, Al‐Khatib S, Birtcher KK, Bozkurt B, Brindis RG, Cigarroa JE, Curtis LH, Fleisher LA, Gentile F, Gidding S, Hlatky MA, Ikonomidis J, Joglar J, Kovacs RJ, Ohman E, Pressler SJ, Sellke FW, Shen W, Wijeysundera DN. 2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST‐elevation myocardial Infarction: An update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST‐elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheterization And Cardiovascular Interventions 2016, 87: 1001-1019. PMID: 26489034, DOI: 10.1002/ccd.26325.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPercutaneous coronary interventionCoronary interventionMyocardial infarctionCardiology/American Heart Association Task ForceACCF/AHA/SCAI guidelinesAmerican Heart Association Task ForcePrimary percutaneous coronary interventionACCF/AHA guidelinesClinical practice guidelinesAHA guidelinesPractice guidelinesCardiovascular AngiographyAmerican CollegeInfarctionInterventionTask ForceGuidelinesAngiographyPatients
2015
National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study
Zhang H, Masoudi FA, Li J, Wang Q, Li X, Spertus JA, Ross JS, Desai NR, Krumholz HM, Jiang L, Group C. National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study. American Heart Journal 2015, 170: 506-515.e1. PMID: 26385034, PMCID: PMC5459420, DOI: 10.1016/j.ahj.2015.05.012.Peer-Reviewed Original ResearchConceptsΒ-blocker therapyAcute myocardial infarctionΒ-blocker useCardiogenic shockRisk factorsAbsolute contraindicationMyocardial infarctionEarly β-blocker useLower systolic blood pressureHours of admissionMedical record reviewSystolic blood pressureClinical practice guidelinesLower heart rateQuality of careChest discomfortCardiac eventsBlood pressureRecord reviewChina PatientIdeal patientPractice guidelinesHeart rateHigh riskPatterns of use
2005
ACCF/ASNC Appropriateness Criteria for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology Endorsed by the American Heart Association
Brindis RG, Douglas PS, Hendel RC, Peterson ED, Wolk MJ, Allen JM, Patel MR, Raskin IE, Hendel RC, Bateman TM, Cerqueira MD, Gibbons RJ, Gillam LD, Gillespie JA, Hendel RC, Iskandrian AE, Jerome SD, Krumholz HM, Messer JV, Spertus JA, Stowers SA. ACCF/ASNC Appropriateness Criteria for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology Endorsed by the American Heart Association. Journal Of The American College Of Cardiology 2005, 46: 1587-1605. PMID: 16226194, DOI: 10.1016/j.jacc.2005.08.029.Peer-Reviewed Original ResearchConceptsTomography myocardial perfusion imagingMyocardial perfusion imagingSingle photon emissionAmerican CollegePerfusion imagingClinical practice guidelinesAmerican Heart AssociationAmerican SocietyReasonable approachNuclear cardiologyPhysician decision makingHealth services researchersHeart AssociationAppropriateness CriteriaAppropriateness reviewClinical indicationsPractice guidelinesCardiology FoundationClinical scenariosWorking GroupCardiovascular imagingNuclear cardiologistsReimbursement policiesScientific evidenceServices researchersIntegrating Clinical Practice Guidelines Into the Routineof Everyday Practice
Brush JE, Radford MJ, Krumholz HM. Integrating Clinical Practice Guidelines Into the Routineof Everyday Practice. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2005, 4: 161-167. PMID: 18340202, DOI: 10.1097/01.hpc.0000173342.41305.b0.Peer-Reviewed Original ResearchClinical practice guidelinesPractice guidelines
2002
Mortality associated with the quality of care of patients hospitalized with congestive heart failure
Luthi J, Mcclellan WM, Fitzgerald D, Krumholz HM, Delaney RJ, Bratzler DW, Elward K, Cangialose C, Ballard D. Mortality associated with the quality of care of patients hospitalized with congestive heart failure. International Journal For Quality In Health Care 2002, 14: 15-24. PMID: 11871625, DOI: 10.1093/intqhc/14.1.15.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCohort StudiesGuideline AdherenceHeart FailureHospital MortalityHospitalizationHumansMedicareOutcome and Process Assessment, Health CarePatient DischargeProportional Hazards ModelsQuality of Health CareRetrospective StudiesRisk AssessmentSurvival AnalysisUnited StatesVentricular Dysfunction, LeftConceptsLeft ventricular systolic dysfunctionCongestive heart failureRisk of deathElderly patientsHazard ratioHeart failurePresence of LVSDAdjusted hazard ratioRetrospective cohort studyUse of angiotensinVentricular systolic dysfunctionClinical practice guidelinesQuality of careACEI doseACEI treatmentSystolic dysfunctionCohort studyDischarge medicationsEjection fractionVentricular functionMean agePractice guidelinesACEIMedicare beneficiariesPatients
2000
Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction? JAMA Internal Medicine 2000, 160: 947-952. PMID: 10761959, DOI: 10.1001/archinte.160.7.947.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryPercutaneous transluminal coronary angioplastyBeta-blocker therapyAcute myocardial infarctionNonrevascularized groupCoronary revascularizationElderly patientsMyocardial infarctionNon-revascularized groupArtery bypass surgeryTransluminal coronary angioplastyClinical practice guidelinesCooperative Cardiovascular ProjectRandomized clinical trialsAmerican Heart AssociationBypass surgerySuccessful revascularizationClinical factorsCoronary angioplastyHeart AssociationPotential confoundersClinical trialsPractice guidelinesRevascularizationAmerican College
1998
Improving the Quality of Care for Medicare Patients With Acute Myocardial Infarction: Results From the Cooperative Cardiovascular Project
Marciniak TA, Ellerbeck EF, Radford MJ, Kresowik TF, Gold JA, Krumholz HM, Kiefe CI, Allman RM, Vogel RA, Jencks SF. Improving the Quality of Care for Medicare Patients With Acute Myocardial Infarction: Results From the Cooperative Cardiovascular Project. JAMA 1998, 279: 1351-1357. PMID: 9582042, DOI: 10.1001/jama.279.17.1351.Peer-Reviewed Original ResearchMeSH KeywordsAlabamaCardiologyCardiology Service, HospitalConnecticutData CollectionHospital MortalityHospitalsHumansIowaMedicareMyocardial InfarctionPilot ProjectsProfessional Review OrganizationsQuality Assurance, Health CareQuality Indicators, Health CareStatistics, NonparametricSurvival AnalysisUnited StatesWisconsinConceptsAcute myocardial infarctionQuality of careMyocardial infarctionMedicare patientsBeta-blocker useAdministration of aspirinClinical practice guidelinesCooperative Cardiovascular ProjectLength of stayAcute care hospitalsQuality improvement projectQuality Improvement ProgramPilot statesPostinfarction mortalityAspirin useCessation counselingCare hospitalPeer review organizationsMedian lengthInpatient claimsPrincipal diagnosisPractice guidelinesInfarctionPatientsMortality comparisons
1997
Quality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospital
1995
Quality of care for Medicare patients with acute myocardial infarction. A four-state pilot study from the Cooperative Cardiovascular Project.
Ellerbeck EF, Jencks SF, Radford MJ, Kresowik TF, Craig AS, Gold JA, Krumholz HM, Vogel RA. Quality of care for Medicare patients with acute myocardial infarction. A four-state pilot study from the Cooperative Cardiovascular Project. JAMA 1995, 273: 1509-14. PMID: 7739077, DOI: 10.1001/jama.273.19.1509.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionQuality of careMedicare patientsMyocardial infarctionRetrospective medical record reviewPercentage of patientsMedical record reviewClinical practice guidelinesCooperative Cardiovascular ProjectAcute care hospitalsHealth care professionalsPrimary hospitalizationInitial hospitalizationCare hospitalRecord reviewStandard treatmentAMI careCare indicatorsPrincipal diagnosisPractice guidelinesAMI therapyMAIN OUTCOMEHospitalizationCare professionalsPatientsQuality of Care for Medicare Patients With Acute Myocardial Infarction: A Four-State Pilot Study From the Cooperative Cardiovascular Project
Ellerbeck E, Jencks S, Radford M, Timothy F, Craig A, Gold J, Krumholz H, Vogel R. Quality of Care for Medicare Patients With Acute Myocardial Infarction: A Four-State Pilot Study From the Cooperative Cardiovascular Project. JAMA 1995, 273: 1509-1514. DOI: 10.1001/jama.1995.03520430045037.Peer-Reviewed Original ResearchAcute myocardial infarctionQuality of careMedicare patientsMyocardial infarctionΒ-blockersRetrospective medical record reviewPercentage of patientsMedical record reviewClinical practice guidelinesCooperative Cardiovascular ProjectAcute care hospitalsHealth care professionalsPrimary hospitalizationInitial hospitalizationCare hospitalRecord reviewStandard treatmentAMI careCare indicatorsPrincipal diagnosisPractice guidelinesAMI therapyHospitalizationCare professionalsPatients