2022
Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort
Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort. JAMA Network Open 2022, 5: e223877. PMID: 35323951, PMCID: PMC8948532, DOI: 10.1001/jamanetworkopen.2022.3877.Peer-Reviewed Original ResearchConceptsDual combination therapyUse of ACEIAntihypertensive drug classesProportion of patientsKhoo Teck Puat HospitalCombination therapyUniversity Hospital databaseHospital databaseDrug classesDual combinationSouth Western Sydney Local Health DistrictWestern Sydney Local Health DistrictPatients age 65 yearsSydney Local Health DistrictElectronic health record databasePatients age 18Local Health DistrictAge 65 yearsTreatment of hypertensionHealth record databaseARB monotherapyTreatment escalationAdult patientsCohort studyCombination regimen
2009
Patterns of Hospital Performance in Acute Myocardial Infarction and Heart Failure 30-Day Mortality and Readmission
Krumholz HM, Merrill AR, Schone EM, Schreiner GC, Chen J, Bradley EH, Wang Y, Wang Y, Lin Z, Straube BM, Rapp MT, Normand SL, Drye EE. Patterns of Hospital Performance in Acute Myocardial Infarction and Heart Failure 30-Day Mortality and Readmission. Circulation Cardiovascular Quality And Outcomes 2009, 2: 407-413. PMID: 20031870, DOI: 10.1161/circoutcomes.109.883256.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureReadmission ratesMyocardial infarctionMortality rateRisk-standardized mortality ratesAge 65 yearsRisk-standardized mortalityHospital referral regionsHospital structural characteristicsType of hospitalHospital performancePrimary diagnosisHospital characteristicsReferral regionsMedicare feeMortalityMedicaid ServicesInfarctionHospitalGeographic differencesReadmissionFailureDiagnosis
2003
Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint
Foody JM, Krumholz HM. Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint. The American Journal Of Geriatric Cardiology 2003, 12: 357-360. PMID: 14610384, DOI: 10.1111/j.1076-7460.2003.02912.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePrimary preventionArtery diseaseOvert coronary artery diseaseRisk of myositisCardiovascular disease eventsRole of statinsUse of statinsAge 65 yearsBalance of risksCardiovascular eventsStatin therapyPatient preferencesCholesterol levelsCardiovascular diseaseOctogenariansClinical uncertaintyDisease eventsCurrent evidenceStatinsAge groupsDiseasePreventionRiskMyositisGender, age, and heart failure with preserved left ventricular systolic function
Masoudi FA, Havranek EP, Smith G, Fish RH, Steiner JF, Ordin DL, Krumholz HM. Gender, age, and heart failure with preserved left ventricular systolic function. Journal Of The American College Of Cardiology 2003, 41: 217-223. PMID: 12535812, DOI: 10.1016/s0735-1097(02)02696-7.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic functionImpaired left ventricular systolic functionVentricular systolic functionHeart failureSystolic functionFemale genderDiagnosis of HFMedical chart abstractionCoronary artery diseasePrincipal discharge diagnosisAge 65 yearsMultivariable logistic regressionCross-sectional studyPotential confounding variablesRenal insufficiencyChart abstractionClinical characteristicsElderly patientsArtery diseaseEjection fractionPulmonary diseasePatient factorsAtrial fibrillationDischarge diagnosisPotential confounders