2011
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
Huang H, Xu Y, van den Pol AN. Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. Journal Of Neurophysiology 2011, 106: 1191-1202. PMID: 21653710, PMCID: PMC3174824, DOI: 10.1152/jn.00740.2010.Peer-Reviewed Original ResearchConceptsAnorexigenic proopiomelanocortin (POMC) neuronsPOMC cellsNPY neuronsProopiomelanocortin neuronsOrexigenic neuropeptide Y (NPY) neuronsHypocretin/orexin neuronsWeight lossNeuropeptide Y cellsWeight-reducing actionsNeuropeptide Y neuronsExcitatory synaptic activityPrevalence of obesityHypothalamic arcuate nucleusΑ4β2 nicotinic receptorsBiggest health problemsSimilar actionsAttenuates ObesityCell typesY neuronsOrexin neuronsCholinergic axonsMembrane potentialNPY cellsArcuate nucleusNicotine action
2007
Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons
Huang H, van den Pol AN. Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons. Journal Of Neuroscience 2007, 27: 11560-11572. PMID: 17959799, PMCID: PMC6673210, DOI: 10.1523/jneurosci.2147-07.2007.Peer-Reviewed Original ResearchConceptsGroup I metabotropic glutamate receptor activationMetabotropic glutamate receptor activationDHPG-induced depolarizationGlutamate receptor activationGroup IHormone neuronsMGluR5 antagonistGreen fluorescent protein-expressing transgenic miceNMDA receptor-mediated postsynaptic currentsReceptor activationExchanger blocker KB-R7943Melanin-concentrating hormone (MCH) neuronsMelanin-Concentrating Hormone NeuronsReceptor-mediated postsynaptic currentsBlockade of mGluR1Selective group IGroup I mGluRsPatch-clamp recordingsMCH neuron activityI mGluRsMCH neuronsHypocretin neuronsSpontaneous EPSCsPostsynaptic mechanismsHypothalamic slicesCannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
Huang H, Acuna-Goycolea C, Li Y, Cheng HM, Obrietan K, van den Pol AN. Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal. Journal Of Neuroscience 2007, 27: 4870-4881. PMID: 17475795, PMCID: PMC6672093, DOI: 10.1523/jneurosci.0732-07.2007.Peer-Reviewed Original ResearchConceptsMelanin-concentrating hormoneHypocretin neuronsMCH cellsCannabinoid actionGreen fluorescent protein-expressing transgenic miceSpike frequencyIonotropic glutamate receptor antagonistsHypocretin/orexin neuronsLocal inhibitory cellsReceptor agonist RSynaptic GABA releaseReceptor antagonist bicucullineGlutamate receptor antagonistsPatch-clamp recordingsGlutamatergic currentsNaphthalenylmethanone mesylatePresynaptic attenuationMiniature IPSCsMCH neuronsAgonist RAntagonist bicucullineGABA releaseOrexin neuronsPostsynaptic effectsSpontaneous IPSCs