Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal
Huang H, Ghosh P, van den Pol AN. Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal. Journal Of Neurophysiology 2006, 95: 1656-1668. PMID: 16492946, DOI: 10.1152/jn.00927.2005.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexParaventricular thalamic nucleusPVT neuronsHcrt-2Hypocretin/orexin neuronsHypothalamic hypocretin/orexin neuronsDirect excitatory actionHcrt receptor 2Magnesium artificial cerebrospinal fluidThalamic paraventricular nucleusCholera toxin subunit BLow-threshold spikesWhole-cell recordingsArtificial cerebrospinal fluidNonselective cation channelsOrexin neuronsExcitatory actionAutonomic functionDense innervationHypocretin-1Hcrt-1Paraventricular nucleusThalamic nucleiCerebrospinal fluidDistinct membrane properties