2022
Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial
Legro RS, Hansen KR, Diamond MP, Steiner AZ, Coutifaris C, Cedars MI, Hoeger KM, Usadi R, Johnstone EB, Haisenleder DJ, Wild RA, Barnhart KT, Mersereau J, Trussell JC, Krawetz SA, Kris-Etherton PM, Sarwer DB, Santoro N, Eisenberg E, Huang H, Zhang H, . Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial. PLOS Medicine 2022, 19: e1003883. PMID: 35041662, PMCID: PMC8765626, DOI: 10.1371/journal.pmed.1003883.Peer-Reviewed Original ResearchConceptsHealthy live birthIntensive lifestyle interventionLifestyle interventionLive birthsWeight lossExercise interventionPrimary outcomeBirth outcomesMetabolic healthInfertility treatmentPhysical activityOvarian stimulation/intrauterine inseminationIntensive groupFirst trimester pregnancy lossIntensive lifestyle groupLifestyle modification groupPreconception lifestyle interventionStandard exercise interventionAcute weight lossTrimester pregnancy lossGastrointestinal side effectsSignificant weight lossLive birth incidenceLifestyle groupUnexplained infertility
2011
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
Huang H, Xu Y, van den Pol AN. Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. Journal Of Neurophysiology 2011, 106: 1191-1202. PMID: 21653710, PMCID: PMC3174824, DOI: 10.1152/jn.00740.2010.Peer-Reviewed Original ResearchConceptsAnorexigenic proopiomelanocortin (POMC) neuronsPOMC cellsNPY neuronsProopiomelanocortin neuronsOrexigenic neuropeptide Y (NPY) neuronsHypocretin/orexin neuronsWeight lossNeuropeptide Y cellsWeight-reducing actionsNeuropeptide Y neuronsExcitatory synaptic activityPrevalence of obesityHypothalamic arcuate nucleusΑ4β2 nicotinic receptorsBiggest health problemsSimilar actionsAttenuates ObesityCell typesY neuronsOrexin neuronsCholinergic axonsMembrane potentialNPY cellsArcuate nucleusNicotine action