Featured Publications
Temperature-Induced uncoupling of cell cycle regulators
Falahati H, Hur W, Di Talia S, Wieschaus E. Temperature-Induced uncoupling of cell cycle regulators. Developmental Biology 2020, 470: 147-153. PMID: 33278404, PMCID: PMC8106975, DOI: 10.1016/j.ydbio.2020.11.010.Peer-Reviewed Original ResearchConceptsCell cycle eventsCycle eventsEarly cell cycle eventsMajor mitotic kinaseCell cycle stepsEarly Drosophila embryoCell cycle progressionCell cycle regulatorsDrosophila embryosMitotic kinasesChromosome condensationDifferent kinasesCdk1 activityEmbryo activationCycle progressionCycle regulatorsEnvironmental variabilityCell cycle transition timesPrometaphaseCDK1KinaseMitosisVivo biosensorsEmbryosIndependent active and thermodynamic processes govern the nucleolus assembly in vivo
Falahati H, Wieschaus E. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1335-1340. PMID: 28115706, PMCID: PMC5307486, DOI: 10.1073/pnas.1615395114.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell NucleolusDrosophila melanogasterDrosophila ProteinsLab-On-A-Chip DevicesNuclear ProteinsThermodynamics
2016
Mitosis-associated repression in development
Esposito E, Lim B, Guessous G, Falahati H, Levine M. Mitosis-associated repression in development. Genes & Development 2016, 30: 1503-1508. PMID: 27401553, PMCID: PMC4949323, DOI: 10.1101/gad.281188.116.Peer-Reviewed Original ResearchConceptsSequence-specific repressorsEarly Drosophila embryoLive-imaging methodsMitotic silencingSnail repressionAnimal developmentSnail repressorDrosophila embryosNascent transcriptsNeurogenic ectodermTranscriptional repressionTarget enhancersPresumptive mesodermReporter geneRepressionRepressorMesodermTranscriptionMitosisEmbryosBroad patternsPervasive featureSilencingEctodermGenes