2018
Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling
Geha P, Yang Y, Estacion M, Schulman B, Tokuno H, Apkarian A, Dib-Hajj S, Waxman S. Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling. 2018, 275-288. DOI: 10.7551/mitpress/10310.003.0031.Peer-Reviewed Original Research
2006
Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord
Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord. Journal Of Neuroscience 2006, 26: 1803-1812. PMID: 16467529, PMCID: PMC2605396, DOI: 10.1523/jneurosci.3611-05.2006.Peer-Reviewed Original ResearchConceptsDemyelinated spinal cordSpecific membrane domainsSpinal cordVoltage-gated ion channelsGreen fluorescent proteinTransplanted Olfactory Ensheathing CellsMature NodalMembrane domainsSpinal cord demyelinationOlfactory Ensheathing CellsVivo electrophysiological recordingsFluorescent proteinJuxtaparanodal domainsMolecular reconstructionIon channelsMature nodesRemyelinated axonsExtensive remyelinationUninjured axonsKv channelsDemyelinated axonsDonor ratsCentral axonsGlial cellsJuxtaparanodal region
2004
Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
Tokuno HA, Bradberry CW, Everill B, Agulian SK, Wilkes S, Baldwin RM, Tamagnan GD, Kocsis JD. Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Brain Research 2004, 996: 159-167. PMID: 14697493, DOI: 10.1016/j.brainres.2003.10.024.Peer-Reviewed Original ResearchConceptsAgonist substitution therapyLocal anesthetic propertiesCompound action potentialSubstitution therapyDorsal rootsAnesthetic propertiesCocaine rewardDorsal root ganglion neuronsSucrose gap chamberUse-dependent blockadeRat peripheral nerveLocal anesthetic effectRat sciatic nerveDopamine uptake inhibitorPotential pharmacological toolsPatch-clamp studiesCAP amplitudeGanglion neuronsSciatic nervePeripheral nervesClinical studiesTreatment candidatesClamp studiesStimulus trainsImpulse blockade