Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
Tokuno HA, Bradberry CW, Everill B, Agulian SK, Wilkes S, Baldwin RM, Tamagnan GD, Kocsis JD. Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Brain Research 2004, 996: 159-167. PMID: 14697493, DOI: 10.1016/j.brainres.2003.10.024.Peer-Reviewed Original ResearchConceptsAgonist substitution therapyLocal anesthetic propertiesCompound action potentialSubstitution therapyDorsal rootsAnesthetic propertiesCocaine rewardDorsal root ganglion neuronsSucrose gap chamberUse-dependent blockadeRat peripheral nerveLocal anesthetic effectRat sciatic nerveDopamine uptake inhibitorPotential pharmacological toolsPatch-clamp studiesCAP amplitudeGanglion neuronsSciatic nervePeripheral nervesClinical studiesTreatment candidatesClamp studiesStimulus trainsImpulse blockade