Endothelial-Specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis
Luo Y, Xu Z, Wan T, He Y, Jones D, Zhang H, Min W. Endothelial-Specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 1307-1314. PMID: 20395596, PMCID: PMC2889154, DOI: 10.1161/atvbaha.110.204222.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsApoptosisCell ProliferationCell SurvivalDisease Models, AnimalEndothelial CellsFemoral ArteryHindlimbHumansIschemiaLigationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMuscle, SkeletalNeovascularization, PhysiologicProtein-Tyrosine KinasesReceptors, Tumor Necrosis Factor, Type IIRecovery of FunctionRegional Blood FlowTime FactorsVascular Endothelial Growth Factor Receptor-2ConceptsFemoral artery ligation modelIschemic reserve capacityLimb perfusion recoveryTNFR2-deficient micePeripheral arterial diseaseCoronary artery diseaseIschemia-induced angiogenesisArtery ligation modelTNFR2 knockoutTNFR2-KOArtery diseaseActivation of TNFR2Adaptive angiogenesisArterial diseaseTg miceVascular diseaseLigation modelPerfusion recoveryAdaptive arteriogenesisVascular endotheliumLower limbsUpper limbGlobal deletionTNFR2Mice