Drosophila PIWI associates with chromatin and interacts directly with HP1a
Brower-Toland B, Findley SD, Jiang L, Liu L, Yin H, Dus M, Zhou P, Elgin SC, Lin H. Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes & Development 2007, 21: 2300-2311. PMID: 17875665, PMCID: PMC1973144, DOI: 10.1101/gad.1564307.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsArgonaute ProteinsBinding SitesChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianFemaleGene SilencingMaleModels, MolecularNuclear ProteinsProtein BindingProteinsRNA-Induced Silencing ComplexConceptsHeterochromatin protein 1aPIWI-interacting RNAsEpigenetic changesChromatin-associated proteinsProtein family membersNormal silencingHeterochromatic genesFly genomeHeterochromatin componentsChromatin modifiersEpigenetic stateEpigenetic regulationRNA mechanismFruit flyPiwiTerminal domainProtein 1ACentral playerRNASpecific sequencesDirect interactionGenomeGenesMotifCellular systems