Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas
Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002, 21: 3988-3999. PMID: 12037681, DOI: 10.1038/sj.onc.1205505.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArgonaute ProteinsBlotting, NorthernChildChromosome MappingChromosomes, Human, Pair 12Cloning, MolecularDNA PrimersDNA, ComplementaryDrosophila ProteinsFormazansGene LibraryHumansImmunoenzyme TechniquesIn Situ HybridizationMaleMolecular Sequence DataPolymerase Chain ReactionProteinsRNA, MessengerRNA-Induced Silencing ComplexSeminomaSequence Homology, Amino AcidTeratomaTesticular NeoplasmsTetrazolium SaltsConceptsGene familyPiwi gene familyHuman membersGerm cellsMolecular characterizationPiwi family genesPIWI family proteinsEnhanced expressionEmbryonic germ cellsGerm cell phenotypeGerm cell characteristicsGerm cell proliferationStage-dependent patternDiverse organismsDrosophila melanogasterC. elegansGermline cellsGenomic regionsFamily genesFamily proteinsSignificant homologySame precursor cellRNA interferenceChromosomal regionsKb mRNAmiwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
Deng W, Lin H. miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis. Developmental Cell 2002, 2: 819-830. PMID: 12062093, DOI: 10.1016/s1534-5807(02)00165-x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsArgonaute ProteinsChromosome MappingCloning, MolecularCyclic AMP Response Element ModulatorCytoplasmDNA-Binding ProteinsGene Expression RegulationInfertility, MaleLIM Domain ProteinsMaleMiceMice, KnockoutMolecular Sequence DataProtein IsoformsProteinsRepressor ProteinsRNA, MessengerSpermatogenesisTestisTranscription FactorsConceptsTarget genesPiwi family genesCytoplasmic protein essentialRound spermatid stageDiverse organismsPiwi genesTranslational regulationFamily genesProtein essentialCytoplasmic proteinsMaster regulatorMurine homologMIWIGenesSpermatid stageStem cellsMRNASpermiogenesisCREMSpermatogenesisSpermatogenic arrestPiwiHomologEncodesCloning