Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains
Chen M, Lin H, Zhao H. Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains. The Annals Of Applied Statistics 2016, 10: 506-526. PMID: 27231496, PMCID: PMC4876974, DOI: 10.1214/16-aoas905.Peer-Reviewed Original ResearchHistone modificationsHistone marksLocal chromatin environmentDistribution of genesWhole-genome analysisRelevant biological functionsEnrichment patternsSimilar enrichment patternsHigh-throughput techniquesChromatin environmentChromatin organizationEpigenetic blockTranscriptional outputGene regulationTranscriptional controlOrchestrated regulationEpigenetic mechanismsGO enrichmentTranscription levelsBiological functionsCombinatorial patternsGenomeGenesRegulationEukaryotes