Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden
Wei L, Christensen SR, Fitzgerald ME, Graham J, Hutson ND, Zhang C, Huang Z, Hu Q, Zhan F, Xie J, Zhang J, Liu S, Remenyik E, Gellen E, Colegio OR, Bax M, Xu J, Lin H, Huss WJ, Foster BA, Paragh G. Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden. Science Advances 2021, 7: eabd7703. PMID: 33523857, PMCID: PMC7775785, DOI: 10.1126/sciadv.abd7703.Peer-Reviewed Original ResearchConceptsSkin cancer riskCancer burdenCancer riskCutaneous squamous cell carcinomaNormal human skin samplesClonal mutationsCarcinogenic effectsSun-exposure statusSquamous cell carcinomaSkin cancer burdenCell carcinomaClonal cell growthNormal skinHuman skin samplesUV exposureUltradeep sequencingUV-induced mutationsSkin samplesCell growthSkinBurdenRiskMutationsExposureUV damage