Featured Publications
Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profileGeneralizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2024
Accessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures
Kim J, Lee J, Thornhill T, Dennett J, Lu H, Howell B, Grau L, Fiellin D, Heimer R, Gonsalves G. Accessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures. JAMA Network Open 2024, 7: e240209. PMID: 38376839, PMCID: PMC10879949, DOI: 10.1001/jamanetworkopen.2024.0209.Peer-Reviewed Original ResearchConceptsTransit travel timeAccessibility metricsTravel timeTravel componentsAccessibility scoresTransportation burdenTravel burdenOut-of-vehicleComponents of travelConventional accessibility measuresSpatial regression modelsTravel time measurementsPublic transitTransit schedulesAccessibility measuresDeparture timeTravel time analysisTrip durationTravelOperating hoursTime analysisCross-sectional studyOpioid use disorderPolicy recommendationsDecision-making
2023
Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial
Zhang Y, Li J, Xie Y, Wu D, Ong J, Marley G, Kamarulzaman A, Lu H, Zou F, Smith J, Tucker J, Fu G, Tang W. Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial. Nature Medicine 2023, 29: 2241-2247. PMID: 37640859, DOI: 10.1038/s41591-023-02519-w.Peer-Reviewed Original ResearchConceptsHepatitis B virusCare armHCV testingVirus testingTwo-arm cluster-randomized trialHepatitis C virus testingHepatitis virus testingCluster-randomized trialProportion of menGroup of menAdverse eventsHBV testPrimary outcomeB virusForward armFree testingHCVMenRapid testingSexTrialsArmActive community participationTestingPersons
2020
Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Hou R, Xie L, Chandrasekar E, Lu H, Wang T, Li C, Xu H. Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Science And Medicine In Sport 2020, 24: 189-194. PMID: 33032913, DOI: 10.1016/j.jsams.2020.09.013.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsBetter cognitionSleep durationLong-term cognitive outcomesDigit Symbol Substitution TestAnimal Fluency TestAssociation of sleepFavorable cognitionsFluency testCognitive outcomesSelf-reported timeSubstitution TestSedentary activitiesPhysical activityCognitionLongitudinal studyExcessive sleepFuture researchNational HealthSleepGlobal Physical Activity QuestionnaireActivity statusPhysical Activity QuestionnaireNutrition Examination Survey
2019
What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men
Tang W, Huang W, Lu H, Cao B, Wu D, Ong J, Fu H, Zhang Y, Yang B, Wang C, Ma W, Wei C, Tucker J. What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men. BMC Infectious Diseases 2019, 19: 807. PMID: 31521123, PMCID: PMC6744670, DOI: 10.1186/s12879-019-4455-8.Peer-Reviewed Original ResearchConceptsFacility-based HIV testingConsistent condom useHIV testingHIV prevention servicesCondom usePrevention servicesStudy periodFacility-based testingMore implementation researchLongitudinal cohort dataHIV testIntervention trialsLongitudinal cohortChinese MSMChinese menHIVSociodemographic informationHIVSTSecondary analysisCohort dataHIVST resultsMost menImplementation researchLinear mixed modelsMenFactors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections
Yang Q, Zhang T, Zhao D, Zhang Y, Dong Y, Sun D, Du Q, Zheng J, Lu H, Dong Y. Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections. Journal Of Clinical Pharmacy And Therapeutics 2019, 45: 72-80. PMID: 31468555, DOI: 10.1111/jcpt.13026.Peer-Reviewed Original ResearchConceptsKidney transplant patientsInvasive fungal infectionsTransplant patientsConcomitant medicationsPlasma concentrationsContinuous renal replacement therapyFungal infectionsRenal replacement therapyUncontrolled observational studiesAntifungal prophylaxisKidney recipientsTrough concentrationsBaseline diseaseReplacement therapyObservational studyHealthy volunteersCyclosporine AProphylaxisHigh incidencePatientsMultivariate analysisMedicationsALB concentrationLiquid chromatography-tandem mass spectrometry methodCandida sppLeading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China
Wu D, Tang W, Lu H, Zhang T, Cao B, Ong J, Lee A, Liu C, Huang W, Fu R, Li K, Pan S, Zhang Y, Fu H, Wei C, Tucker J. Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China. Journal Of Medical Internet Research 2019, 21: e10171. PMID: 30664490, PMCID: PMC6360381, DOI: 10.2196/10171.Peer-Reviewed Original ResearchConceptsSyphilis testingMale sex partnersHealth influencersSTI informationSex partnersSociodemographic characteristicsSyphilis testing ratesUnknown HIV statusSexual behaviorInternet-Using MenLogistic regression modelsHealthy HIVHigh HIVHIV testingHIV statusMSM populationHigher oddsCondomless sexHIVTesting ratesHealthy behaviorsLeast college educationWeb-based surveyMale partnersMost menLate-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Ying M, Xie L, Chandrasekar E, Lu H, Wang T, Li C. Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Psychiatric Research 2019, 111: 30-35. PMID: 30660811, DOI: 10.1016/j.jpsychires.2019.01.012.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsLate-life depressionExecutive function/processing speedLower cognitionDepressive symptomsDomain-specific cognitive functionDigit Symbol Substitution TestAnimal Fluency TestWord recall testDelayed Word Recall TestLower cognitive functionRecall testOverall cognitionFluency testProcessing speedCognitionCognitive depressive symptomsSubstitution TestNational HealthZ-scoreSpecific domainsDepressionMultivariable linear regression modelsPatient Health QuestionnaireRecalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China
Cao B, Saha P, Leuba S, Lu H, Tang W, Wu D, Ong J, Liu C, Fu R, Wei C, Tucker J. Recalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China. AIDS And Behavior 2019, 23: 1240-1249. PMID: 30632008, PMCID: PMC6511317, DOI: 10.1007/s10461-019-02392-0.Peer-Reviewed Original Research
2018
Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial
Tang W, Wei C, Cao B, Wu D, Li K, Lu H, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Liu C, Huang W, Liu A, Zhang Y, Smith M, Mitchell K, Ong J, Fu H, Vickerman P, Yang L, Wang C, Zheng H, Yang B, Tucker J. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLOS Medicine 2018, 15: e1002645. PMID: 30153265, PMCID: PMC6112627, DOI: 10.1371/journal.pmed.1002645.Peer-Reviewed Original ResearchConceptsHIV testing servicesFacility-based HIV testingHIV testingHIV testSecondary outcomesSyphilis testingIntervention periodClosed cohortWedge clusterCommunity-based HIV testing servicesCondom useSelf-reported HIV testingTesting servicesControl periodHIV testing campaignsHIV testing dataHIV testing ratesHIV testing strategiesHIV testing uptakeSubset of menHIV testing interventionsMiddle-income countriesPrimary outcomeTreat analysisCluster RCTDevelopment and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database
Zhao Y, Lu H, Thai S, Li X, Hui J, Tang H, Zhai S, Sun L, Wang T. Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database. International Journal Of Clinical Pharmacy 2018, 40: 862-869. PMID: 29464448, DOI: 10.1007/s11096-018-0594-z.Peer-Reviewed Original ResearchConceptsDrug-induced anaphylaxisBeijing Pharmacovigilance DatabasePositive predictive valueAdverse drug eventsPharmacovigilance databaseAnaphylactic shockSpecific diagnosisSerious adverse drug eventsPhysician adjudicatorsChart abstractionAnaphylactic reactionsClinical criteriaDrug eventsAnaphylactoid reactionsMAIN OUTCOMEPredictive valueAnaphylaxisDiagnosisGold standardConfidence intervalsPatientsCriteria componentsHospitalDatabaseGreater number
2017
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults
Gross A, Lu H, Meoni L, Gallo J, Schrack J, Sharrett A. Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. Journal Of Alzheimer's Disease 2017, 59: 1349-1358. PMID: 28759969, DOI: 10.3233/jad-170290.Peer-Reviewed Original ResearchConceptsPhysical activityCox proportional hazards modelLate-life cognitionMidlife physical activityPhysical activity measuresProportional hazards modelOnset of dementiaCognitive testsNormal older adultsCross-sectional findingsRandomized trialsRegular exerciseMetabolic equivalentsDementia onsetObservational studyHazards modelDementiaActivity measuresCognitive healthOlder adultsBetter cognitionCross-sectional dataLater lifeCohortNull findings