Featured Publications
Toward a Clearer Definition of Selection Bias When Estimating Causal Effects
Lu H, Cole S, Howe C, Westreich D. Toward a Clearer Definition of Selection Bias When Estimating Causal Effects. Epidemiology 2022, 33: 699-706. PMID: 35700187, PMCID: PMC9378569, DOI: 10.1097/ede.0000000000001516.Peer-Reviewed Original ResearchRevisiting Overadjustment Bias
Lu H, Cole S, Platt R, Schisterman E. Revisiting Overadjustment Bias. Epidemiology 2021, 32: e22-e23. PMID: 34172691, DOI: 10.1097/ede.0000000000001377.Peer-Reviewed Original ResearchBiasHumansClinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2020, 73: e1408-e1414. PMID: 32780095, PMCID: PMC8492356, DOI: 10.1093/cid/ciaa1037.Peer-Reviewed Original ResearchConceptsIntegrase strand transfer inhibitorsHuman immunodeficiency virusHazard ratioEFV groupAntiretroviral therapyStrand transfer inhibitorsClinical outcomesRisk differenceINSTI groupComposite outcomeImmunodeficiency virusClinical effectivenessNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyEnd-stage liver diseaseLong-term clinical effectivenessEnd-stage renal diseaseLong-term clinical outcomesComposite clinical outcomeFirst ART regimenInitial ART regimensAdverse clinical outcomesModern antiretroviral therapyTransfer inhibitorsAcute myocardial infarctionInflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profileGeneralizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2023
Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial
Zhang Y, Li J, Xie Y, Wu D, Ong J, Marley G, Kamarulzaman A, Lu H, Zou F, Smith J, Tucker J, Fu G, Tang W. Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial. Nature Medicine 2023, 29: 2241-2247. PMID: 37640859, DOI: 10.1038/s41591-023-02519-w.Peer-Reviewed Original ResearchConceptsHepatitis B virusCare armHCV testingVirus testingTwo-arm cluster-randomized trialHepatitis C virus testingHepatitis virus testingCluster-randomized trialProportion of menGroup of menAdverse eventsHBV testPrimary outcomeB virusForward armFree testingHCVMenRapid testingSexTrialsArmActive community participationTestingPersonsOptimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine
Jetsupphasuk M, Hudgens M, Lu H, Cole S, Edwards J, Adimora A, Althoff K, Silverberg M, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Moore R, Lang R, Gebo K, Rabkin C, Eron J. Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine. American Journal Of Epidemiology 2023, 192: 1341-1349. PMID: 36922393, PMCID: PMC10666965, DOI: 10.1093/aje/kwad057.Peer-Reviewed Original ResearchConceptsEfavirenz-based regimenAntiretroviral therapyPatient characteristicsComposite outcomeNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapySerious non-AIDS eventsHuman immunodeficiency virus (HIV) treatmentIntegrase strand transfer inhibitorsSame drug regimenBaseline patient characteristicsNon-AIDS eventsAbsolute risk reductionSubgroup of patientsHuman immunodeficiency virusIndividual patient characteristicsImmune deficiency syndromePrecision medicineStrand transfer inhibitorsCohort CollaborationCause mortalityDrug regimenClinical outcomesImmunodeficiency virusDeficiency syndromeGeographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019
Lu H, Crawford F, Gonsalves G, Grau L. Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019. Annals Of Epidemiology 2023, 79: 32-38. PMID: 36669599, PMCID: PMC10163838, DOI: 10.1016/j.annepidem.2023.01.009.Peer-Reviewed Original Research
2022
Eliminating conversion therapy and promoting LGBTQ-affirmative therapy in China
Li G, Qin S, Lu H, Santtila P, Hall B. Eliminating conversion therapy and promoting LGBTQ-affirmative therapy in China. The Lancet Psychiatry 2022, 9: e25. PMID: 35569506, DOI: 10.1016/s2215-0366(22)00120-1.Peer-Reviewed Original Research
2021
Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy. AIDS 2021, 36: 277-286. PMID: 34934020, PMCID: PMC9048218, DOI: 10.1097/qad.0000000000003069.Peer-Reviewed Original ResearchConceptsEFV groupINSTI groupVirologic outcomesAntiretroviral therapyART initiationIntegrase inhibitor-based antiretroviral therapyNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyInhibitor-based antiretroviral therapyLong-term virologic outcomesIntegrase strand transfer inhibitorsFirst ART regimenInitial ART regimensRapid virologic responseStrand transfer inhibitorsART regimenCohort CollaborationInitial regimensVirologic responseVirologic suppressionART regimensVirologic effectsTreat analysisHIV treatmentLong-term effects
2020
Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Hou R, Xie L, Chandrasekar E, Lu H, Wang T, Li C, Xu H. Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Science And Medicine In Sport 2020, 24: 189-194. PMID: 33032913, DOI: 10.1016/j.jsams.2020.09.013.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsBetter cognitionSleep durationLong-term cognitive outcomesDigit Symbol Substitution TestAnimal Fluency TestAssociation of sleepFavorable cognitionsFluency testCognitive outcomesSelf-reported timeSubstitution TestSedentary activitiesPhysical activityCognitionLongitudinal studyExcessive sleepFuture researchNational HealthSleepGlobal Physical Activity QuestionnaireActivity statusPhysical Activity QuestionnaireNutrition Examination SurveyWhat we talk about when we talk about durable viral suppression.
Diepstra K, Lu H, McManus K, Rogawski McQuade E, Rhodes A, Westreich D. What we talk about when we talk about durable viral suppression. AIDS 2020, 34: 1683-1686. PMID: 32732633, PMCID: PMC7845768, DOI: 10.1097/qad.0000000000002612.Peer-Reviewed Original Research
2019
What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men
Tang W, Huang W, Lu H, Cao B, Wu D, Ong J, Fu H, Zhang Y, Yang B, Wang C, Ma W, Wei C, Tucker J. What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men. BMC Infectious Diseases 2019, 19: 807. PMID: 31521123, PMCID: PMC6744670, DOI: 10.1186/s12879-019-4455-8.Peer-Reviewed Original ResearchConceptsFacility-based HIV testingConsistent condom useHIV testingHIV prevention servicesCondom usePrevention servicesStudy periodFacility-based testingMore implementation researchLongitudinal cohort dataHIV testIntervention trialsLongitudinal cohortChinese MSMChinese menHIVSociodemographic informationHIVSTSecondary analysisCohort dataHIVST resultsMost menImplementation researchLinear mixed modelsMenFactors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections
Yang Q, Zhang T, Zhao D, Zhang Y, Dong Y, Sun D, Du Q, Zheng J, Lu H, Dong Y. Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections. Journal Of Clinical Pharmacy And Therapeutics 2019, 45: 72-80. PMID: 31468555, DOI: 10.1111/jcpt.13026.Peer-Reviewed Original ResearchConceptsKidney transplant patientsInvasive fungal infectionsTransplant patientsConcomitant medicationsPlasma concentrationsContinuous renal replacement therapyFungal infectionsRenal replacement therapyUncontrolled observational studiesAntifungal prophylaxisKidney recipientsTrough concentrationsBaseline diseaseReplacement therapyObservational studyHealthy volunteersCyclosporine AProphylaxisHigh incidencePatientsMultivariate analysisMedicationsALB concentrationLiquid chromatography-tandem mass spectrometry methodCandida sppLeading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China
Wu D, Tang W, Lu H, Zhang T, Cao B, Ong J, Lee A, Liu C, Huang W, Fu R, Li K, Pan S, Zhang Y, Fu H, Wei C, Tucker J. Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China. Journal Of Medical Internet Research 2019, 21: e10171. PMID: 30664490, PMCID: PMC6360381, DOI: 10.2196/10171.Peer-Reviewed Original ResearchConceptsSyphilis testingMale sex partnersHealth influencersSTI informationSex partnersSociodemographic characteristicsSyphilis testing ratesUnknown HIV statusSexual behaviorInternet-Using MenLogistic regression modelsHealthy HIVHigh HIVHIV testingHIV statusMSM populationHigher oddsCondomless sexHIVTesting ratesHealthy behaviorsLeast college educationWeb-based surveyMale partnersMost menLate-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Ying M, Xie L, Chandrasekar E, Lu H, Wang T, Li C. Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Psychiatric Research 2019, 111: 30-35. PMID: 30660811, DOI: 10.1016/j.jpsychires.2019.01.012.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsLate-life depressionExecutive function/processing speedLower cognitionDepressive symptomsDomain-specific cognitive functionDigit Symbol Substitution TestAnimal Fluency TestWord recall testDelayed Word Recall TestLower cognitive functionRecall testOverall cognitionFluency testProcessing speedCognitionCognitive depressive symptomsSubstitution TestNational HealthZ-scoreSpecific domainsDepressionMultivariable linear regression modelsPatient Health QuestionnaireRecalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China
Cao B, Saha P, Leuba S, Lu H, Tang W, Wu D, Ong J, Liu C, Fu R, Wei C, Tucker J. Recalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China. AIDS And Behavior 2019, 23: 1240-1249. PMID: 30632008, PMCID: PMC6511317, DOI: 10.1007/s10461-019-02392-0.Peer-Reviewed Original Research
2018
Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial
Tang W, Wei C, Cao B, Wu D, Li K, Lu H, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Liu C, Huang W, Liu A, Zhang Y, Smith M, Mitchell K, Ong J, Fu H, Vickerman P, Yang L, Wang C, Zheng H, Yang B, Tucker J. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLOS Medicine 2018, 15: e1002645. PMID: 30153265, PMCID: PMC6112627, DOI: 10.1371/journal.pmed.1002645.Peer-Reviewed Original ResearchConceptsHIV testing servicesFacility-based HIV testingHIV testingHIV testSecondary outcomesSyphilis testingIntervention periodClosed cohortWedge clusterCommunity-based HIV testing servicesCondom useSelf-reported HIV testingTesting servicesControl periodHIV testing campaignsHIV testing dataHIV testing ratesHIV testing strategiesHIV testing uptakeSubset of menHIV testing interventionsMiddle-income countriesPrimary outcomeTreat analysisCluster RCTDevelopment and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database
Zhao Y, Lu H, Thai S, Li X, Hui J, Tang H, Zhai S, Sun L, Wang T. Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database. International Journal Of Clinical Pharmacy 2018, 40: 862-869. PMID: 29464448, DOI: 10.1007/s11096-018-0594-z.Peer-Reviewed Original ResearchConceptsDrug-induced anaphylaxisBeijing Pharmacovigilance DatabasePositive predictive valueAdverse drug eventsPharmacovigilance databaseAnaphylactic shockSpecific diagnosisSerious adverse drug eventsPhysician adjudicatorsChart abstractionAnaphylactic reactionsClinical criteriaDrug eventsAnaphylactoid reactionsMAIN OUTCOMEPredictive valueAnaphylaxisDiagnosisGold standardConfidence intervalsPatientsCriteria componentsHospitalDatabaseGreater number
2017
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults
Gross A, Lu H, Meoni L, Gallo J, Schrack J, Sharrett A. Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. Journal Of Alzheimer's Disease 2017, Preprint: 1-10. PMID: 28759969, DOI: 10.3233/jad-170290.Peer-Reviewed Original ResearchConceptsPhysical activityCox proportional hazards modelLate-life cognitionMidlife physical activityPhysical activity measuresProportional hazards modelOnset of dementiaCognitive testsNormal older adultsCross-sectional findingsRandomized trialsRegular exerciseMetabolic equivalentsDementia onsetObservational studyHazards modelDementiaActivity measuresCognitive healthOlder adultsBetter cognitionCross-sectional dataLater lifeCohortNull findings