2023
Building a Quality Practice in Chronic Pancreatitis
Kothari D, Ketwaroo G, Sheth S. Building a Quality Practice in Chronic Pancreatitis. Journal Of Clinical Gastroenterology 2023, 57: 265-268. PMID: 36598825, DOI: 10.1097/mcg.0000000000001824.Peer-Reviewed Original ResearchConceptsChronic pancreatitisManagement of CPMyriad of symptomsChemical dependencyAbdominal painEndoscopic therapyPain managementIrreversible scarringFibroinflammatory disorderPancreatic parenchymaPatientsWeight lossPancreatitisCenters of excellenceNauseaSteatorrheaPainDiabetesScarringTherapySymptomsAvailable dataParenchymaRecent literature
2022
AGA Institute Quality Measure Development for Intragastric Balloons in the Management of Obesity
Ketwaroo G, Newberry C, Kushnir V, Sheth S, Leiman D, ASSOCIATION Q. AGA Institute Quality Measure Development for Intragastric Balloons in the Management of Obesity. Gastroenterology 2022, 163: 350-353. PMID: 35472323, DOI: 10.1053/j.gastro.2022.04.022.Peer-Reviewed Original ResearchExternal validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans
Nguyen T, Thrift A, Ketwaroo G, Du X, Leon Novelo L, George R, Rosen D, El-Serag H. External validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans. Gastrointestinal Endoscopy 2022, 95: 1113-1122. PMID: 34998796, PMCID: PMC9119926, DOI: 10.1016/j.gie.2021.12.034.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaHigh-risk groupEsophageal adenocarcinomaBarrett's esophagusBE patientsDiscriminatory abilityHouston Veterans Affairs Medical CenterVeterans Affairs Medical CenterHGD/esophageal adenocarcinomaRetrospective cohort studyExternal validationExternal validation studyInitial EGDCohort studyConsecutive patientsSmoking statusDysplasia statusRisk groupsMedical CenterHigh riskGeneral populationNew diagnosisPatientsClinical practiceBiopsy sampling
2021
Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans
Jiao L, Kourkoumpetis T, Hutchinson D, Ajami N, Hoffman K, White D, Graham D, Hair C, Shah R, Kanwal F, Jarbrink-Sehgal M, Husain N, Hernaez R, Hou J, Cole R, Velez M, Ketwaroo G, Kramer J, El-Serag H, Petrosino J. Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans. Microbial Ecology 2021, 83: 811-821. PMID: 34223947, DOI: 10.1007/s00248-021-01789-6.Peer-Reviewed Original ResearchConceptsAmplicon sequence variantsBacterial community compositionCommunity compositionMucosa-associated gut microbiotaTaxonomic structureSignificant differencesRelative abundanceColonic biopsiesEscherichia/ShigellaInter-individual variabilityColonic segmentsColon segmentsFunctional capacityGut microbiotaLarge intestineFree adultsColonic bacteriaRRNA geneCompositional dissimilarityMajor phylaFecal bacteriaSequencing dataLimited dataPrevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population
Nguyen T, Thrift A, George R, Rosen D, El-Serag H, Ketwaroo G. Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population. Clinical Gastroenterology And Hepatology 2021, 20: e876-e889. PMID: 33839273, PMCID: PMC8900254, DOI: 10.1016/j.cgh.2021.04.008.Peer-Reviewed Original ResearchConceptsBarrett's esophagusIndex esophagogastroduodenoscopyIndefinite dysplasiaBE diagnosisLong-segment Barrett's esophagusProportion of patientsSegment Barrett's esophagusDysplastic Barrett's esophagusLogistic regression modelsBE lengthDefinite dysplasiaHouston VANDBE patientsClose followInitial biopsyDysplasia surveillanceBE patientsEndoscopic samplingRisk factorsOdds ratioEsophagogastroduodenoscopyRetrospective analysisPatientsVeteran populationDysplasia
2020
AGA Institute Quality Measure Development for the Diagnosis and Management of COVID-19
Leiman D, Maratt J, Ketwaroo G, Association Q. AGA Institute Quality Measure Development for the Diagnosis and Management of COVID-19. Gastroenterology 2020, 160: 985-992. PMID: 33242519, PMCID: PMC7683301, DOI: 10.1053/j.gastro.2020.11.039.Peer-Reviewed Original ResearchAccuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria
Souza D, Alessandrino F, Ketwaroo G, Sawhney M, Mortele K. Accuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria. La Radiologia Medica 2020, 125: 816-826. PMID: 32266691, DOI: 10.1007/s11547-020-01181-3.Peer-Reviewed Original Research
2019
Development of Quality Measures for Acute Pancreatitis: A Model for Hospital-Based Measures in Gastroenterology
Mosko J, Leiman D, Ketwaroo G, Gupta N, Association Q. Development of Quality Measures for Acute Pancreatitis: A Model for Hospital-Based Measures in Gastroenterology. Clinical Gastroenterology And Hepatology 2019, 18: 272-275.e5. PMID: 31760190, DOI: 10.1016/j.cgh.2019.11.033.Peer-Reviewed Original ResearchRational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain
Ketwaroo G, Graham D. Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain. Advances In Experimental Medicine And Biology 2019, 1148: 323-343. PMID: 31482505, PMCID: PMC6913179, DOI: 10.1007/978-981-13-7709-9_14.Peer-Reviewed Original ResearchConceptsPancreatic insufficiencyPancreatic enzymesPancreatic painPancreatic secretionEndogenous pancreatic secretionTreatment of malabsorptionProton pump inhibitorsEnteric-coated formulationCoated formulationPump inhibitorsSuccessful therapySuboptimal effectNutritional deficitsPainDistal intestineNutritional deficienciesRational useInsufficiencyMalabsorptionGood responseTherapySecretionIntestineEnteric coatingDigestive contentsDietary quality and the colonic mucosa–associated gut microbiome in humans
Liu Y, Ajami N, El-Serag H, Hair C, Graham D, White D, Chen L, Wang Z, Plew S, Kramer J, Cole R, Hernaez R, Hou J, Husain N, Jarbrink-Sehgal M, Kanwal F, Ketwaroo G, Natarajan Y, Shah R, Velez M, Mallepally N, Petrosino J, Jiao L. Dietary quality and the colonic mucosa–associated gut microbiome in humans. American Journal Of Clinical Nutrition 2019, 110: 701-712. PMID: 31291462, PMCID: PMC6736447, DOI: 10.1093/ajcn/nqz139.Peer-Reviewed Original ResearchConceptsTotal HEIColonic mucosaHigher BacteroidesDietary qualityGut microbiomeCross-sectional observational studyLower scoresColonic mucosal biopsiesHealthy Eating IndexDifferent colon segmentsMucosal biopsiesMultivariable analysisObservational studyColon segmentsDietary consumptionHealthy individualsMultivariate analysisFree participantsMucosaNormal individualsFusobacteriumWhole grainsTaxonomic relative abundancesScoresSoy beverageQuality of Care Indicators in Patients with Acute Pancreatitis
Ketwaroo G, Sealock R, Freedman S, Hart P, Othman M, Wassef W, Banks P, Vege S, Gardner T, Yadav D, Sheth S, Kanwal F. Quality of Care Indicators in Patients with Acute Pancreatitis. Digestive Diseases And Sciences 2019, 64: 2514-2526. PMID: 31152333, DOI: 10.1007/s10620-019-05674-8.Peer-Reviewed Original ResearchConceptsExplicit quality indicatorsQuality of careCandidate quality indicatorsDetermination of etiologyCare of patientsDetermination of severityFuture quality improvementBackgroundAcute pancreatitisEndoscopic therapyFluid resuscitationSurgical managementRisk stratificationAcute pancreatitisCare indicatorsPatient outcomesQI setPatient carePatientsComprehensive literature reviewLiterature reviewQuality indicatorsExpensive conditionsStandardized techniqueProcess measuresCareDietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
Gurwara S, Ajami N, Jang A, Hessel F, Chen L, Plew S, Wang Z, Graham D, Hair C, White D, Kramer J, Kourkoumpetis T, Hoffman K, Cole R, Hou J, Husain N, Jarbrink-Sehgal M, Hernaez R, Kanwal F, Ketwaroo G, Shah R, Velez M, Natarajan Y, El-Serag H, Petrosino J, Jiao L. Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon. Nutrients 2019, 11: 613. PMID: 30871224, PMCID: PMC6470629, DOI: 10.3390/nu11030613.Peer-Reviewed Original ResearchConceptsB vitaminsDietary consumptionGut microbiotaMucosa-associated gut microbiotaConsumption of folateFood frequency questionnaireHigh consumptionFrequency questionnaireColonic biopsiesNormal colonGut microbiomeColonic bacteriaOne-carbon metabolismDaily consumptionOperational taxonomic unit classificationStatistical significanceDietary nutrientsTaxonomic relative abundancesVitaminFolateMicrobiotaERCP Success Rate and Periampullary Diverticula: The Pocket Makes No Difference
Ketwaroo G, Qureshi W. ERCP Success Rate and Periampullary Diverticula: The Pocket Makes No Difference. Digestive Diseases And Sciences 2019, 64: 1072-1073. PMID: 30734235, DOI: 10.1007/s10620-019-05497-7.Peer-Reviewed Original ResearchScope of Burnout Among Young Gastroenterologists and Practical Solutions from Gastroenterology and Other Disciplines
Barnes E, Ketwaroo G, Shields H. Scope of Burnout Among Young Gastroenterologists and Practical Solutions from Gastroenterology and Other Disciplines. Digestive Diseases And Sciences 2019, 64: 302-306. PMID: 30607687, DOI: 10.1007/s10620-018-5443-3.Peer-Reviewed Original Research
2018
Enzyme therapy for functional bowel disease‐like post‐prandial distress
Graham D, Ketwaroo G, Money M, Opekun A. Enzyme therapy for functional bowel disease‐like post‐prandial distress. Journal Of Digestive Diseases 2018, 19: 650-656. PMID: 30101562, PMCID: PMC6910206, DOI: 10.1111/1751-2980.12655.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeBowel syndromeDiarrhea-predominant irritable bowel syndromeRandomized placebo-controlled trialDouble-blinded randomizedPost-prandial distressPost-prandial symptomsPlacebo-controlled studyPlacebo-controlled trialFeeling of fullnessAbdominal distensionGastrointestinal symptomsMulti-enzyme preparationUnknown etiologyDisaccharidase deficiencySymptom responseCommon complaintRecent trialsClinical trialsSpecific symptomsCombination drugsEnzyme therapyNarrative reviewSuccessful useSymptomsHow to Incorporate Quality Improvement and Patient Safety Projects in Your Training
Siddique S, Ketwaroo G, Newberry C, Mathews S, Khungar V, Mehta S. How to Incorporate Quality Improvement and Patient Safety Projects in Your Training. Gastroenterology 2018, 154: 1564-1568. PMID: 29604243, PMCID: PMC5931739, DOI: 10.1053/j.gastro.2018.03.044.Peer-Reviewed Original Research
2017
Mechanical colon cleansing for screening colonoscopy: A randomized controlled trial
Ayub K, Ketwaroo G, Abudayyeh S, Ibrahim A, Cole R, Brumfield‐Brown R, Qureshi W, Rabeneck L, Graham D. Mechanical colon cleansing for screening colonoscopy: A randomized controlled trial. Journal Of Digestive Diseases 2017, 18: 691-697. PMID: 29160622, DOI: 10.1111/1751-2980.12562.Peer-Reviewed Original ResearchThe Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing
Kothari D, Ketwaroo G, Freedman S, Sheth S. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas 2017, 46: 887-890. PMID: 28697128, DOI: 10.1097/mpa.0000000000000871.Peer-Reviewed Original ResearchConceptsRecurrent acute pancreatitisPeak bicarbonate concentrationHistory of APAcute pancreatitisRisk factorsPancreatic function testingChronic pancreatitisLocal complicationsFunction testingFemale sexBicarbonate concentrationRetrospective reviewUnivariate analysisFamily historyTobacco usePancreatitisPatientsMultivariate analysisAlcohol useComplicationsSignificant differencesSexFactorsHistoryComparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis
Kothari D, Ketwaroo G, Sawhney M, Freedman S, Sheth S. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis. Pancreas 2017, 46: 770-775. PMID: 28609365, DOI: 10.1097/mpa.0000000000000829.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCross-Over StudiesEndoscopes, GastrointestinalEndoscopy, GastrointestinalEndosonographyFeasibility StudiesFemaleHumansMaleMiddle AgedPancreatic Function TestsPancreatic JuicePancreatitis, ChronicPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSecretinTime FactorsWorkflowConceptsChronic pancreatitisPeak bicarbonate concentrationPancreatic function testsEndoscopic ultrasonographyFunction testsPoor concordanceProspective crossover studyPancreatic function testingFunctional testsBicarbonate concentrationPeak bicarbonateSecretin testingCrossover studyFunction testingTest concordanceDiscordant findingsFunctional assessmentPatientsImproved concordancePancreatitisSignificant correlationUltrasonographyConcordanceFeasible testCutoffHow to Create an Unfunded Teaching Fellowship During the Gastroenterology Fellowship That Positively Impacts Subsequent Teaching Activities and Career Path
Shields H, Fellows T, Goldberg E, Somers S, Travassos W, Ullman S, Maroo S, Leffler D, O’Farrell P, Blanco P, Kappler S, Berzin T, Flier S, Sepe P, Magee S, Ketwaroo G, Feuerstein J, Perencevich M, Vaughn B, Barnes E, Nayeb-Hashemi H, Borges L, Kim W, Pelletier S. How to Create an Unfunded Teaching Fellowship During the Gastroenterology Fellowship That Positively Impacts Subsequent Teaching Activities and Career Path. Gastroenterology 2017, 152: 689-692. PMID: 28153607, DOI: 10.1053/j.gastro.2017.01.026.Peer-Reviewed Original Research