2015
Epidemiology of multiple sclerosis: results from a large observational study in the UK
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Epidemiology of multiple sclerosis: results from a large observational study in the UK. Journal Of Neurology 2015, 262: 2033-2041. PMID: 26067217, PMCID: PMC4768220, DOI: 10.1007/s00415-015-7796-2.Peer-Reviewed Original ResearchConceptsUnderlying autoimmune processHazard ratioCause mortalityAutoimmune processMS patientsUK Clinical Practice Research DatalinkClinical Practice Research DatalinkIncident MS casesAdjusted hazard ratioUrinary tract infectionCox proportional regressionMultiple sclerosis progressionPrimary care dataConfidence intervalsLarge observational studiesIdentification of predictorsOriginal medical recordsCurrent smokingPatient comorbiditiesTract infectionsFrequent comorbiditiesLifestyle factorsMS diagnosisMultiple sclerosisPatient group
2014
Mortality of patients with multiple sclerosis: a cohort study in UK primary care
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Mortality of patients with multiple sclerosis: a cohort study in UK primary care. Journal Of Neurology 2014, 261: 1508-1517. PMID: 24838537, PMCID: PMC4119255, DOI: 10.1007/s00415-014-7370-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedMultiple SclerosisPrimary Health CareRisk FactorsSurvival AnalysisUnited KingdomConceptsCause of deathMS patientsCause mortalityHazard ratioMS casesUK General Practice Research DatabaseGeneral Practice Research DatabaseLarge population-based cohortFirst MS diagnosisMortality of patientsFemale MS patientsCox proportional regressionMultiple sclerosis patientsPopulation-based cohortUK primary careConfidence intervalsDifferent hazard ratiosHR 1.7Index dateCohort studyYounger patientsHigher proportionSclerosis patientsMS diagnosisMultiple sclerosis