2024
Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy background
2020
Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH
Murthy S, Roh DJ, Chatterjee A, McBee N, Parikh NS, Merkler AE, Navi BB, Falcone GJ, Sheth KN, Awad I, Hanley D, Kamel H, Ziai WC. Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH. Journal Of Neurology Neurosurgery & Psychiatry 2020, 92: 364-369. PMID: 33106367, PMCID: PMC8071838, DOI: 10.1136/jnnp-2020-323458.Peer-Reviewed Original ResearchPrior antiplatelet therapyAntiplatelet therapyLobar intracerebral hemorrhageIntracerebral hemorrhagePrimary intracerebral hemorrhageHaematoma expansionHaematoma volumeHaematoma locationCause mortalityIII trialsStudy cohortMajor disabilitySecondary analysisIndividual patient-level analysisPhase III trialsLarge heterogeneous cohortIndividual patient dataPatient-level analysisMISTIE IIISecondary outcomesDeep hemorrhagesPrimary outcomeICH locationMRS distributionFunctional outcome