Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset
Witsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset. Neurocritical Care 2021, 35: 418-427. PMID: 33479920, PMCID: PMC8578176, DOI: 10.1007/s12028-020-01180-2.Peer-Reviewed Original ResearchConceptsLoss of consciousnessIntraventricular hemorrhageIntracerebral hemorrhageSymptom onsetICH onsetUnfavorable outcomeAdmission Glasgow Coma ScoreAdmission systolic blood pressureOnset of ICHGlasgow Coma ScoreSystolic blood pressureSpontaneous intracerebral hemorrhageAdmission serum glucoseThousand seven hundredVolumetric CT measurementsBackgroundIn patientsComa ScoreBlood pressureMedical chartsICH volumeMental statusSerum glucoseICH casesInclusion criteriaPatientsAndexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ. Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage. Neurocritical Care 2021, 35: 255-261. PMID: 33403588, PMCID: PMC10273779, DOI: 10.1007/s12028-020-01161-5.Peer-Reviewed Original ResearchConceptsFactor Xa inhibitorsSpontaneous intracranial hemorrhageSpontaneous intraparenchymal hemorrhageAndexanet alfaIntracranial hemorrhageProthrombin complex concentrateThrombotic eventsIntraparenchymal hemorrhageFunctional outcomeComplex concentrateXa inhibitorsFour-factor prothrombin complex concentrateOnset of ICHConsecutive adult patientsGood functional outcomeModified Rankin scoreSubgroup of patientsNumber of patientsThromboembolic eventsRankin scoreAdult patientsMedian ageRetrospective reviewHematoma volumeResultsA total