Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression
Pearson-Fuhrhop KM, Dunn EC, Mortero S, Devan WJ, Falcone GJ, Lee P, Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Rosand J, Cramer SC. Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression. PLOS ONE 2014, 9: e93772. PMID: 24834916, PMCID: PMC4023941, DOI: 10.1371/journal.pone.0093772.Peer-Reviewed Original ResearchConceptsGenetic risk scoreRisk scoreHealthy adult participantsDepressive symptomatologyAdult participantsPathophysiology of depressionDopamine receptor bindingSynaptic dopamine availabilityDiscovery sampleReplication sampleDopamine-related genesDopamine metabolismMonoamine neurotransmissionDepressive symptomsDopamine neurotransmissionHealthy individualsHealthy adultsFunctional polymorphismsHuman disabilityDopamine availabilityReceptor bindingDepressionEtiologic insightsAdultsFurther studies