2024
A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials.
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Pereira Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 17407745241276137. PMID: 39377196, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized estimating equationsPermutationMedian sample sizeIntervention conditionRandomization methodEquationsHIV Symptom Clusters Among Sexual Minority Men in Ghana, West Africa: A Cross-sectional Study.
Akyirem S, Tong G, Aidoo-Frimpong G, Abwoye D, López D, Wilton L, Nelson L. HIV Symptom Clusters Among Sexual Minority Men in Ghana, West Africa: A Cross-sectional Study. Journal Of The Association Of Nurses In AIDS Care 2024 PMID: 39208416, DOI: 10.1097/jnc.0000000000000497.Peer-Reviewed Original ResearchSelf-concept/self-esteemSymptom clustersSexual minority menAssociated with higher distress scoresGastrointestinal symptom clusterLate HIV diagnosisHigher distress scoresSeven symptom clustersAnalyzed cross-sectional dataMinority menCross-sectional studyMultivariate linear regressionCross-sectional dataHIV symptomsDistress scoresHIV diagnosisPsychological symptomsPrevalent symptomsSymptom identificationSymptomsHIVLinear regressionClinical characteristicsNegative Life Events and Emotional Symptoms From Ages 2 to 30 Years
Copeland W, Keen R, Tong G, Shanahan L. Negative Life Events and Emotional Symptoms From Ages 2 to 30 Years. JAMA Network Open 2024, 7: e2429448. PMID: 39207754, PMCID: PMC11362870, DOI: 10.1001/jamanetworkopen.2024.29448.Peer-Reviewed Original ResearchConceptsCross-sectional analysisEmotional symptomsNegative life eventsAssociated with emotional symptomsLife eventsYoung adulthoodAssociated with increased mental health symptomsCohort study analyzed dataStressful eventsTraumatic eventsMental health symptomsCross-sectional associationsLongitudinal analysisAged 2Years of follow-upStudy analyzed dataDevelopmental periodIndividuals aged 2Lifetime traumatic eventsHealth symptomsMain OutcomesLate adolescenceEmotional functioningCohort studyPrimary outcomeTrends in Firearm Injury Prevention Research Funding, Clinical Trials, and Publications in the US, 1985-2022
Lin J, Chang C, McCarthy M, Baker-Butler A, Tong G, Ranney M. Trends in Firearm Injury Prevention Research Funding, Clinical Trials, and Publications in the US, 1985-2022. JAMA Surgery 2024, 159: 461-463. PMID: 38324281, PMCID: PMC10851134, DOI: 10.1001/jamasurg.2023.7461.Peer-Reviewed Original ResearchSociodemographic correlates of late HIV diagnosis among men who have sex with men (MSM) in Ghana
Aidoo-Frimpong G, Tong G, Akyirem S, Abwoye D, Nwanaji-Enwerem U, López D, Wilton L, Nelson L. Sociodemographic correlates of late HIV diagnosis among men who have sex with men (MSM) in Ghana. AIDS Care 2024, 36: 807-815. PMID: 38460152, DOI: 10.1080/09540121.2024.2325071.Peer-Reviewed Original ResearchLate HIV diagnosisHIV diagnosisOlder age groupsFactors associated with late HIV diagnosisIncreased risk of late diagnosisAge groupsRisk of late diagnosisImprove public health outcomesBurden of HIVAge-related disparitiesSame-gender sexual contactPublic health outcomesViral load suppressionExposure to HIVMedical engagementTailored interventionsHealth outcomesSociodemographic correlatesMedical servicesTargeted interventionsGhanaian menMSMDemographic variablesIncreased riskInterventionA BAYESIAN MACHINE LEARNING APPROACH FOR ESTIMATING HETEROGENEOUS SURVIVOR CAUSAL EFFECTS: APPLICATIONS TO A CRITICAL CARE TRIAL.
Chen X, Harhay M, Tong G, Li F. A BAYESIAN MACHINE LEARNING APPROACH FOR ESTIMATING HETEROGENEOUS SURVIVOR CAUSAL EFFECTS: APPLICATIONS TO A CRITICAL CARE TRIAL. The Annals Of Applied Statistics 2024, 18: 350-374. PMID: 38455841, PMCID: PMC10919396, DOI: 10.1214/23-aoas1792.Peer-Reviewed Original ResearchHierarchical Bayesian modeling of heterogeneous outcome variance in cluster randomized trials
Tong G, Tong J, Jiang Y, Esserman D, Harhay M, Warren J. Hierarchical Bayesian modeling of heterogeneous outcome variance in cluster randomized trials. Clinical Trials 2024, 21: 451-460. PMID: 38197388, PMCID: PMC11233424, DOI: 10.1177/17407745231222018.Peer-Reviewed Original Research
2023
Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022
Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Tong G, Wang X, Ortiz-Reyes L, Caille A, Li F, Taljaard M. Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022. Clinical Trials 2023, 21: 199-210. PMID: 37990575, PMCID: PMC11003836, DOI: 10.1177/17407745231208397.Peer-Reviewed Original ResearchA mixed model approach to estimate the survivor average causal effect in cluster‐randomized trials
Wang W, Tong G, Hirani S, Newman S, Halpern S, Small D, Li F, Harhay M. A mixed model approach to estimate the survivor average causal effect in cluster‐randomized trials. Statistics In Medicine 2023, 43: 16-33. PMID: 37985966, DOI: 10.1002/sim.9939.Peer-Reviewed Original ResearchViolent Experiences and Patterns of Firearm Ownership From Childhood to Young Adulthood
Sivaraman J, Tong G, Easter M, Swanson J, Copeland W. Violent Experiences and Patterns of Firearm Ownership From Childhood to Young Adulthood. JAMA Network Open 2023, 6: e2336907. PMID: 37851447, PMCID: PMC10585415, DOI: 10.1001/jamanetworkopen.2023.36907.Peer-Reviewed Original ResearchConceptsGun ownershipGun accessViolent experiencesFirearm accessGun cultureViolent exposuresLate 20sGun ownersFirearm ownershipViolent eventsYoung adulthoodSurvey dataIncident rate ratiosOwnershipViolenceRural countiesOpportune timeAge cohortsAge 25First waveAccessConsistent accessHigher relative riskGreat Smoky Mountains StudyExperienceDesigning multicenter individually randomized group treatment trials
Tong G, Tong J, Li F. Designing multicenter individually randomized group treatment trials. Biometrical Journal 2023, 66: e2200307. PMID: 37768850, DOI: 10.1002/bimj.202200307.Peer-Reviewed Original ResearchIntergenerational Effects of a Family Cash Transfer on the Home Environment
Copeland W, Tong G, Shanahan L, Rothenberg W, Lansford J, Godwin J, Rybińska A, Odgers C, Dodge K. Intergenerational Effects of a Family Cash Transfer on the Home Environment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 336-344. PMID: 37619938, PMCID: PMC11290693, DOI: 10.1016/j.jaac.2023.08.001.Peer-Reviewed Original ResearchCash transfersGreat Smoky Mountains StudyCash transfer programEnvironment indicatorsParental mental healthComposite measureIntergenerational effectsLong-term effectsElevated riskHome environmentIncome supplementMental healthSubstance useTransfer programsChild growthTribal membersLate 30sMountains StudyBeneficial outcomesAmerican IndiansParticipantsChildhoodChildrenLittle evidenceNatural experimentTrusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence
Tong G, Spell V, Horton N, Thornhill T, Keene D, Montgomery C, Spiegelman D, Wang E, Roy B. Trusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence. BMC Public Health 2023, 23: 1545. PMID: 37580653, PMCID: PMC10426138, DOI: 10.1186/s12889-023-15997-x.Peer-Reviewed Original ResearchConceptsGun violenceHousing assistanceStructural racismHousing stabilityViolence exposureMulti-level interventionsCommunity gun violenceMulti-stakeholder coalitionsRental assistance programsCommunity-based organizationsHousing supportPolicy changesFinancial educationStable housingBeing of individualsViolenceTarget neighborhoodsCommunity membersNew HavenNeighborhood ratesAssistance programsOrganization leadersRacismHavenNeighborhoodSample size considerations for assessing treatment effect heterogeneity in randomized trials with heterogeneous intracluster correlations and variances
Tong G, Taljaard M, Li F. Sample size considerations for assessing treatment effect heterogeneity in randomized trials with heterogeneous intracluster correlations and variances. Statistics In Medicine 2023, 42: 3392-3412. PMID: 37316956, DOI: 10.1002/sim.9811.Peer-Reviewed Original ResearchConceptsGroup treatment trialsTreatment effect modificationRandomized trialsTreatment trialsEffect modificationEffect modifiersIntracluster correlation coefficientIndividual-level effect modifiersStudy armsTreatment effect heterogeneityOutcome observationsContinuous outcomesTrialsGroup treatmentTreatment effectsOutcome varianceEffect heterogeneityIntracluster correlationSample sizeSample size formulaParental supervision positively impacts children's economic prospects two decades later: A prospective longitudinal study.
McGinnis EW, Halvorson-Phelan J, Shanahan L, Guangyu T, Copeland W. Parental supervision positively impacts children's economic prospects two decades later: A prospective longitudinal study. PLoS One 2023, 18: e0286218. PMID: 37224161, DOI: 10.1371/journal.pone.0286218.Peer-Reviewed Original ResearchCultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults
Copeland W, Ivanova M, Achenbach T, Turner L, Tong G, Ahmeti-Pronaj A, Au A, Bellina M, Caldas J, Chen Y, Csemy L, da Rocha M, Dobrean A, Ezpeleta L, Funabiki Y, Harder V, Lecannelier F, de la Cabada M, Leung P, Liu J, Mahr S, Malykh S, Markovic J, Ndetei D, Oh K, Petot J, Riad G, Sakarya D, Samaniego V, Sebre S, Shahini M, Silvares E, Simulioniene R, Sokoli E, Talcott J, Vazquez N, Wolanczyk T, Zasepa E. Cultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults. Psychological Medicine 2023, 53: 7581-7590. PMID: 37203460, DOI: 10.1017/s0033291723001332.Peer-Reviewed Original ResearchConceptsMental health problemsAnxiety problemsAvoidant personalityProblem scaleAdult self-ratingsAdult mental health problemsOrganizational Behavior Effectiveness studyHierarchical linear modelingCross-cultural useAnalysis of covarianceSomatic problemsHealth problemsSelf-ratingsPersonal strengthsGender effectsStandardized measuresAssociated with differencesStrength scaleMulti-level analysisCultural differencesSocietal differencesAdultsEffectiveness studiesPersonsCultural clustersAccounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity
Tong J, Li F, Harhay M, Tong G. Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity. BMC Medical Research Methodology 2023, 23: 85. PMID: 37024809, PMCID: PMC10077680, DOI: 10.1186/s12874-023-01887-8.Peer-Reviewed Original ResearchConceptsSample size methodsSample size proceduresSize proceduresTreatment effect heterogeneityHeterogeneous treatment effectsSize methodMissingness ratesSample size formulaSample size estimationMissingness indicatorsEffect heterogeneityReal-world examplesSimulation studyIntracluster correlation coefficientInflation methodSize formulaAverage treatment effectResultsSimulation resultsSample size estimatesSize estimationMissingnessSample sizeClustersEstimationFormulaA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReportingA Bayesian Approach for Estimating the Survivor Average Causal Effect When Outcomes Are Truncated by Death in Cluster-Randomized Trials
Tong G, Li F, Chen X, Hirani S, Newman S, Wang W, Harhay M. A Bayesian Approach for Estimating the Survivor Average Causal Effect When Outcomes Are Truncated by Death in Cluster-Randomized Trials. American Journal Of Epidemiology 2023, 192: 1006-1015. PMID: 36799630, PMCID: PMC10236525, DOI: 10.1093/aje/kwad038.Peer-Reviewed Original Research
2022
Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs
Sung M, Viera A, Esserman D, Tong G, Davidson D, Aiudi S, Bailey G, Buchanan A, Buchelli M, Jenkins M, John B, Kolakowski J, Lame A, Murphy S, Porter E, Simone L, Paris M, Rash C, Edelman E. Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs. Contemporary Clinical Trials 2022, 125: 107037. PMID: 36460267, PMCID: PMC9918697, DOI: 10.1016/j.cct.2022.107037.Peer-Reviewed Original ResearchConceptsAdherence support servicesHIV risk reductionPrEP adherenceContingency managementHybrid type 1 effectiveness-implementation trialHIV pre-exposure prophylaxisEffectiveness-implementation studyPre-exposure prophylaxisEffectiveness-implementation trialOpioid use disorderStrengths-based case managementRisk reductionSupport servicesCommunity-based programsPrEP initiationPrimary outcomeWeek 12Clinical trialsHIV preventionUse disordersCM sessionsCase managementBlood spotsPWIDStudy design