2010
Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats
Hermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology & Behavior 2010, 104: 354-359. PMID: 21185848, PMCID: PMC3387788, DOI: 10.1016/j.physbeh.2010.12.019.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBehavioral SymptomsBody WeightDisks Large Homolog 4 ProteinEstriolEstrusExploratory BehaviorFemaleFood DeprivationGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsMembrane ProteinsPrefrontal CortexPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSocial IsolationSynapsinsConceptsFemale ratsNovelty-suppressed feeding testPrefrontal cortexSocial isolationPost-weaning social isolationSynapse-related proteinsChronic social isolationFemale Sprague-DawleyEarly life stressorsSerotonergic functionGlutamate receptorsSprague-DawleyMale rodentsMaternal separationProtein PSD95Profound dysregulationNeuropsychiatric disordersBrain developmentRatsAnxiety disordersMarked deficitDeprivation resultsProtein expressionAdult animalsBiochemical effects
2008
Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden
Hermes GL, McClintock MK. Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden. Developmental Psychobiology 2008, 50: 353-360. PMID: 18393277, DOI: 10.1002/dev.20295.Peer-Reviewed Original ResearchConceptsMammary tumor burdenTumor burdenOvarian functionMammary gland developmentOvarian systemGreater tumor burdenGland developmentSpontaneous mammary tumorsSocial isolationMammary tissue developmentRisk factorsBreast cancerMammary tumorsOvarian senescenceEpidemiological studiesBreast parenchymaEarly pubertyRatsYoung adulthoodNorway ratsPubertyPsychosocial experiencesBurdenAgeEstropause