2009
Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 22393-22398. PMID: 20018726, PMCID: PMC2799783, DOI: 10.1073/pnas.0910753106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCorticosteroneEndocrine GlandsFemaleHumansMammary Neoplasms, ExperimentalOvaryRatsRats, Sprague-DawleyReceptors, GlucocorticoidRisk FactorsSocial EnvironmentSocial IsolationStress, PhysiologicalStress, PsychologicalConceptsDuctal carcinomaBreast cancerCorticosterone responseTumor developmentMammary tumor burdenProgesterone receptor statusEarly breast cancerMammary tumor growthInvasive ductal carcinomaSprague-Dawley ratsMammary tumor progressionAge-matched controlsSpontaneous mammary tumorsLife Span StudyMalignant burdenTumor estrogenReceptor statusTumor burdenOvarian functionFemale ratsMammary tumorsRelative riskTumor growthPsychosocial stressorsTumor progression
2005
Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor
Hermes GL, Rosenthal L, Montag A, McClintock MK. Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor. AJP Regulatory Integrative And Comparative Physiology 2005, 290: r273-r282. PMID: 16210419, DOI: 10.1152/ajpregu.00368.2005.Peer-Reviewed Original ResearchConceptsChronic social isolationInflammatory responseSocial isolationAnimal studiesPrior stressorsInnate inflammatory responseRobust inflammatory responseNumerous epidemiological studiesFemale Sprague-DawleyLong-term social isolationFirst animal studyAdverse psychological statesSex differencesNumerous disease processesInflammatory processSubcutaneous injectionSprague-DawleyLong-term effectsEpidemiological studiesDisease processShort-term effectsAcute stressSignificant sex differencesYoung adulthoodIsolated males