2010
Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats
Hermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology & Behavior 2010, 104: 354-359. PMID: 21185848, PMCID: PMC3387788, DOI: 10.1016/j.physbeh.2010.12.019.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBehavioral SymptomsBody WeightDisks Large Homolog 4 ProteinEstriolEstrusExploratory BehaviorFemaleFood DeprivationGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsMembrane ProteinsPrefrontal CortexPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSocial IsolationSynapsinsConceptsFemale ratsNovelty-suppressed feeding testPrefrontal cortexSocial isolationPost-weaning social isolationSynapse-related proteinsChronic social isolationFemale Sprague-DawleyEarly life stressorsSerotonergic functionGlutamate receptorsSprague-DawleyMale rodentsMaternal separationProtein PSD95Profound dysregulationNeuropsychiatric disordersBrain developmentRatsAnxiety disordersMarked deficitDeprivation resultsProtein expressionAdult animalsBiochemical effects
2008
Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden
Hermes GL, McClintock MK. Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden. Developmental Psychobiology 2008, 50: 353-360. PMID: 18393277, DOI: 10.1002/dev.20295.Peer-Reviewed Original ResearchConceptsMammary tumor burdenTumor burdenOvarian functionMammary gland developmentOvarian systemGreater tumor burdenGland developmentSpontaneous mammary tumorsSocial isolationMammary tissue developmentRisk factorsBreast cancerMammary tumorsOvarian senescenceEpidemiological studiesBreast parenchymaEarly pubertyRatsYoung adulthoodNorway ratsPubertyPsychosocial experiencesBurdenAgeEstropause
2005
Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor
Hermes GL, Rosenthal L, Montag A, McClintock MK. Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor. AJP Regulatory Integrative And Comparative Physiology 2005, 290: r273-r282. PMID: 16210419, DOI: 10.1152/ajpregu.00368.2005.Peer-Reviewed Original ResearchConceptsChronic social isolationInflammatory responseSocial isolationAnimal studiesPrior stressorsInnate inflammatory responseRobust inflammatory responseNumerous epidemiological studiesFemale Sprague-DawleyLong-term social isolationFirst animal studyAdverse psychological statesSex differencesNumerous disease processesInflammatory processSubcutaneous injectionSprague-DawleyLong-term effectsEpidemiological studiesDisease processShort-term effectsAcute stressSignificant sex differencesYoung adulthoodIsolated males