Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 22393-22398. PMID: 20018726, PMCID: PMC2799783, DOI: 10.1073/pnas.0910753106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCorticosteroneEndocrine GlandsFemaleHumansMammary Neoplasms, ExperimentalOvaryRatsRats, Sprague-DawleyReceptors, GlucocorticoidRisk FactorsSocial EnvironmentSocial IsolationStress, PhysiologicalStress, PsychologicalConceptsDuctal carcinomaBreast cancerCorticosterone responseTumor developmentMammary tumor burdenProgesterone receptor statusEarly breast cancerMammary tumor growthInvasive ductal carcinomaSprague-Dawley ratsMammary tumor progressionAge-matched controlsSpontaneous mammary tumorsLife Span StudyMalignant burdenTumor estrogenReceptor statusTumor burdenOvarian functionFemale ratsMammary tumorsRelative riskTumor growthPsychosocial stressorsTumor progression