Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function
Buscariollo DL, Breuer GA, Wendler CC, Rivkees SA. Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function. PLOS ONE 2011, 6: e28296. PMID: 22164264, PMCID: PMC3229565, DOI: 10.1371/journal.pone.0028296.Peer-Reviewed Original ResearchConceptsReceptor-selective antagonistHeart rateA1 adenosine receptorsCardiac functionAdenosine receptorsRoom airNormal cardiac responseElevated heart rateEmbryonic cardiac functionEffects of caffeineCardiac A1 adenosine receptorsAdenosine actionA1AR expressionEmbryonic hypoxiaSCH 58261Isolated heartCaffeine exposureA1AR activationCardiac responseHeart functionCaffeine altersA2aAR geneA1AR actionHypoxiaReal-time PCR analysis