2010
Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR
Patel AB, de Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR. Cerebrovascular And Brain Metabolism Reviews 2010, 30: 1200-1213. PMID: 20125180, PMCID: PMC2879471, DOI: 10.1038/jcbfm.2010.2.Peer-Reviewed Original Research
2006
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose
Mason GF, Petersen KF, De Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose. Journal Of Neurochemistry 2006, 100: 73-86. PMID: 17076763, PMCID: PMC2995551, DOI: 10.1111/j.1471-4159.2006.04200.x.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexCerebral cortexArterial-venous differencesAwake humansNeurotransmitter cyclingGlutamine effluxNeurotransmitter traffickingOccipital-parietal regionsGlutamateCortexPyruvate carboxylase fluxRecent studiesGlutamine synthesisPyruvate carboxylaseMagnetic resonance spectroscopyMost studiesGlutaminePyruvate dehydrogenase
2001
Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein
Mason G, Martin D, Martin S, Manor D, Sibson N, Patel A, Rothman D, Behar K. Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein. Brain Research 2001, 914: 81-91. PMID: 11578600, DOI: 10.1016/s0006-8993(01)02778-0.Peer-Reviewed Original ResearchConceptsTotal GAD activityGAD activityNon-treated control groupGABA-transaminase inhibitionNitrous oxide anesthesiaCortex of controlGlutamate-glutamine cyclingGlutamic acid decarboxylaseGABA synthesis rateGamma-aminobutyric acid (GABA) synthesisVigabatrin treatmentOxide anesthesiaRat cortexGAD67 proteinControl groupBasal conditionsAcid decarboxylaseEx vivoNeuronal compartmentsVigabatrinQuantitative immunoblottingIsoform compositionRatsCortexInhibitionIn vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
1999
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
Shen J, Petersen K, Behar K, Brown P, Nixon T, Mason G, Petroff O, Shulman G, Shulman R, Rothman D. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8235-8240. PMID: 10393978, PMCID: PMC22218, DOI: 10.1073/pnas.96.14.8235.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cycleGlutamine cycleCerebral cortexMin/Rat cerebral cortexVivo 13C NMR spectraGlucose oxidation ratesHuman brainGlucose oxidationGlutamatergic activityRat modelTricarboxylic acid cycle rateParietal lobeHuman cortexCortexTime courseBrainGlutamine synthesisMajor metabolic fluxCycle rateTricarboxylic acid cycleHigh levelsInfusionRatsAcid cycle
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo resultsStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling
Sibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.Peer-Reviewed Original Research
1996
Spectroscopic imaging of human brain glutamate by water‐suppressed J‐refocused coherence transfer at 4.1 T
Pan J, Mason G, Pohost G, Hetherington H. Spectroscopic imaging of human brain glutamate by water‐suppressed J‐refocused coherence transfer at 4.1 T. Magnetic Resonance In Medicine 1996, 36: 7-12. PMID: 8795013, DOI: 10.1002/mrm.1910360103.Peer-Reviewed Original Research
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T
Mason G, Pan J, Ponder S, Twieg D, Pohost G, Hetherington H. Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T. Magnetic Resonance In Medicine 1994, 32: 142-145. PMID: 7916115, DOI: 10.1002/mrm.1910320121.Peer-Reviewed Original Research