Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 211-221. PMID: 19794401, PMCID: PMC2949111, DOI: 10.1038/jcbfm.2009.197.Peer-Reviewed Original ResearchConceptsNeuronal mitochondrial metabolismHealthy agingBrain mitochondrial metabolismElderly subjectsYoung subjectsBrain functionBrain mitochondrial functionGlutamate-glutamine cyclingMitochondrial metabolismVivo magnetic resonance spectroscopyAge-related changesChronic reductionLabeling of glutamineGlutamate concentrationYoung volunteersBiologic basisMagnetic resonance spectroscopyMitochondrial functionMetabolismSubjectsIndividual subjectsResonance spectroscopyTricarboxylic acid cycleCycle fluxAging