2019
Lack of correlation of virulence gene profiles of Staphylococcus aureus bacteremia isolates with mortality
Park K, Greenwood-Quaintance K, Cunningham S, Rajagopalan G, Chia N, Jeraldo P, Mandrekar J, Patel R. Lack of correlation of virulence gene profiles of Staphylococcus aureus bacteremia isolates with mortality. Microbial Pathogenesis 2019, 133: 103543. PMID: 31102653, DOI: 10.1016/j.micpath.2019.103543.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnimalsBacteremiaBacterial AdhesionBase SequenceCell ProliferationDrug Resistance, BacterialFemaleHLA-DR3 AntigenHumansImmune EvasionMaleMethicillin-Resistant Staphylococcus aureusMiceMice, TransgenicMiddle AgedMinnesotaPolymerase Chain ReactionStaphylococcal InfectionsStaphylococcus aureusSuperantigensVirulenceVirulence FactorsConceptsMethicillin-susceptible S. aureusS. aureus bacteremiaAureus bacteremiaMedical CenterHLA-DR3 transgenic miceStaphylococcus aureus bacteremiaMinnesota Medical CenterLarge medical centerImmune evasion genesVirulence genesVirulence gene profilesNumber of deathsClinical dataClinical valueTransgenic miceClinical practiceIndividual PCR assaysWhole-genome sequencing analysisMortalitySAg genesSurvivorsLack of correlationBacteremiaWGS analysisFunctional assays
2017
Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome*
Festic E, Carr G, Cartin-Ceba R, Hinds R, Banner-Goodspeed V, Bansal V, Asuni A, Talmor D, Rajagopalan G, Frank R, Gajic O, Matthay M, Levitt J. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome*. Critical Care Medicine 2017, 45: 798-805. PMID: 28240689, PMCID: PMC5392150, DOI: 10.1097/ccm.0000000000002284.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdministration, InhalationAdrenal Cortex HormonesAdrenergic beta-AgonistsAgedAged, 80 and overBiomarkersBudesonide, Formoterol Fumarate Drug CombinationDouble-Blind MethodDrug Therapy, CombinationFemaleHumansHypoxiaMaleMiddle AgedOxygenPatient AcuityRespiration, ArtificialRespiratory Distress SyndromeRisk FactorsUnited StatesConceptsAcute respiratory distress syndromeRespiratory distress syndromeBudesonide/formoterolDistress syndromeBeta agonistsMore patientsMechanical ventilationClinical trialsEarly treatmentFirst study drugAlveolar fluid clearanceEffective pharmacologic treatmentRandomized clinical trialsPlacebo bidCategorical changePlacebo groupStudy drugAdult patientsLung inflammationLung injuryPharmacologic treatmentPrimary outcomeMedian timeEmergency departmentImproved oxygenation
2014
Superantigens in Staphylococcus aureus isolated from prosthetic joint infection
Kim C, Karau M, Greenwood-Quaintance K, Tilahun A, David C, Mandrekar J, Patel R, Rajagopalan G. Superantigens in Staphylococcus aureus isolated from prosthetic joint infection. Diagnostic Microbiology And Infectious Disease 2014, 81: 201-207. PMID: 25619753, PMCID: PMC4336809, DOI: 10.1016/j.diagmicrobio.2014.11.007.Peer-Reviewed Original ResearchSuperantigen profiling of Staphylococcus aureus infective endocarditis isolates
Chung J, Karau M, Greenwood-Quaintance K, Ballard A, Tilahun A, Khaleghi S, David C, Patel R, Rajagopalan G. Superantigen profiling of Staphylococcus aureus infective endocarditis isolates. Diagnostic Microbiology And Infectious Disease 2014, 79: 119-124. PMID: 24745820, PMCID: PMC4031024, DOI: 10.1016/j.diagmicrobio.2014.03.009.Peer-Reviewed Original ResearchConceptsSuperantigen genesSplenocyte proliferationS. aureusStaphylococcus aureus infective endocarditisMethicillin-susceptible S. aureusMethicillin-resistant S. aureusInfective endocarditis casesEnzyme-linked immunosorbent assayStaphylococcal enterotoxin AInfective endocarditisEndocarditis casesSuperantigen productionMouse splenocyte proliferationPCR-positive isolatesTSST-1EndocarditisImmunosorbent assayEnterotoxin AStaphylococcus aureusAureusProliferationIsolatesMortalityGenes