Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment
Nie Z, Aboulnasr F, Natesampillai S, Burke S, Krogman A, Bren G, Chung T, Anderson J, Smart M, Katzmann D, Rajagopalan G, Cummins N, Badley A. Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment. The Journal Of Immunology 2018, 200: 1110-1123. PMID: 29263214, PMCID: PMC5808399, DOI: 10.4049/jimmunol.1701113.Peer-Reviewed Original ResearchConceptsTRAIL resistanceBystander cellsNeighboring bystander cellsUninfected bystander cellsType I IFNsOvercoming TRAIL ResistanceTRAIL receptor 1Apoptosis-inducing ligandHIV diseaseTLR9 agonistsImmune eliminationReceptor axisTRAILshortI IFNsSpecific AbsHIVReceptor 1Tumor cellsTRAIL sensitivityNormal cellsDominant negative ligandCellsSplice variantsMicroenvironmentKilling