2015
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo
Hoffmann M, Molina-Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, Rajagopalan G, Pease L, Schrum A, Gil D. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Science Advances 2015, 1: e1500415. PMID: 26601285, PMCID: PMC4646799, DOI: 10.1126/sciadv.1500415.Peer-Reviewed Original ResearchT cell responsesTCR/CD3T cell receptorWeak antigensCell responsesTCR/CD3 engagementWeak T cell responsesCD3 engagementMelanoma lung metastasisStrong immune responseAnti-melanoma immunotherapyImmune reactivityLung metastasesTherapeutic responseImmunotherapeutic designT cellsT lymphocytesImmune responseAdaptive immunityStrong antigenReceptor subunitsCell receptorAntigenCD3Antigen recognition
2011
Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock Syndrome
Tilahun A, Marietta E, Wu T, Patel R, David C, Rajagopalan G. Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock Syndrome. American Journal Of Pathology 2011, 178: 2760-2773. PMID: 21641398, PMCID: PMC3124354, DOI: 10.1016/j.ajpath.2011.02.033.Peer-Reviewed Original ResearchConceptsToxic shock syndromeShock syndromeTransgenic miceSmall intestineHLA-DR3 transgenic miceHLA class II moleculesMultiple organ inflammationPotent T cell activatorsKey pathogenic eventClass II moleculesT cell activatorsGut dysfunctionKawasaki diseaseLiver failureHeavy infiltrationHigh morbidityD-GalN.Pathologic changesT lymphocytesExtrahepatic pathologyPathogenic eventsAbsorptive functionD-galactosamineSensitization modelMouse strains
2004
In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists
Rajagopalan G, Sen M, David C. In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists. Infection And Immunity 2004, 72: 6733-6737. PMID: 15501813, PMCID: PMC522998, DOI: 10.1128/iai.72.11.6733-6737.2004.Peer-Reviewed Original Research