Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo
Hoffmann M, Molina-Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, Rajagopalan G, Pease L, Schrum A, Gil D. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Science Advances 2015, 1: e1500415. PMID: 26601285, PMCID: PMC4646799, DOI: 10.1126/sciadv.1500415.Peer-Reviewed Original ResearchT cell responsesTCR/CD3T cell receptorWeak antigensCell responsesTCR/CD3 engagementWeak T cell responsesCD3 engagementMelanoma lung metastasisStrong immune responseAnti-melanoma immunotherapyImmune reactivityLung metastasesTherapeutic responseImmunotherapeutic designT cellsT lymphocytesImmune responseAdaptive immunityStrong antigenReceptor subunitsCell receptorAntigenCD3Antigen recognition