2012
Linezolid Is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA Class II Transgenic Mice
Karau M, Tilahun A, Schmidt S, Clark C, Patel R, Rajagopalan G. Linezolid Is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA Class II Transgenic Mice. Antimicrobial Agents And Chemotherapy 2012, 56: 5401-5405. PMID: 22850509, PMCID: PMC3457354, DOI: 10.1128/aac.01080-12.Peer-Reviewed Original ResearchConceptsHLA class II transgenic miceTransgenic miceDR3 transgenic miceII transgenic miceHuman leukocyte antigenS. aureusC57BL/6 miceLeukocyte antigenStaphylococcus aureus virulenceExperimental pneumoniaImmune systemSuperantigensPneumoniaAureus virulenceMiceBacterial protein synthesis inhibitorsProtein synthesis inhibitorStaphylococcus aureusLinezolidPotent activatorSynthesis inhibitorVancomycinAureusGreater protectionSuperior response
2003
Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor-α Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II Molecules
Rajagopalan G, Kudva YC, Flavell RA, David CS. Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor-α Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II Molecules. Diabetes 2003, 52: 342-347. PMID: 12540606, DOI: 10.2337/diabetes.52.2.342.Peer-Reviewed Original ResearchConceptsClass II moleculesNecrosis factorT cellsHLA class II associationsHuman type 1 diabetesMajor histocompatibility class II moleculesFunctional class II moleculesClass II associationsType 1 diabetesRat insulin promoterTumor necrosis factorLocal proinflammatory environmentIslets of LangerhansAccelerated diabetesNOD miceHLA-DQ8Proinflammatory environmentC57BL/6 miceTNF-alphaDiabetesDisease pathogenesisSignificant protectionMajor histocompatibility complex locusNeonatal expressionMice