The clinical spectrum and treatment of Lyme disease.
Steere A, Malawista S, Bartenhagen N, Spieler P, Newman J, Rahn D, Hutchinson G, Green J, Snydman D, Taylor E. The clinical spectrum and treatment of Lyme disease. The Yale Journal Of Biology And Medicine 1984, 57: 453-61. PMID: 6516448, PMCID: PMC2590003.Peer-Reviewed Original ResearchConceptsLyme diseaseHigh-dose intravenous penicillinJuvenile rheumatoid arthritisEarly Lyme diseaseErosion of cartilageErythema chronicum migransB-cell alloantigensIntravenous penicillinRheumatoid arthritisClinical spectrumProlonged illnessMultisystem disorderCardiac abnormalitiesIntermittent attacksEffective drugsPatientsDiseaseArthritisIllnessWeeksPenicillinSeparate entitiesGeographic clusteringAlloantigensLater stages