1987
Treatment of Lyme disease
Steere A, Green J, Hutchinson G, Rahn D, Pachner A, Schoen R, Sigal L, Taylor E, Malawista S. Treatment of Lyme disease. International Journal Of Medical Microbiology 1987, 263: 352-356. PMID: 3109144, DOI: 10.1016/s0176-6724(87)80092-5.Peer-Reviewed Original ResearchConceptsPenicillin-treated patientsLyme diseaseHigh-dose intravenous penicillinAttacks of arthritisIntravenous penicillin GHalf of patientsMajor late complicationsEarly Lyme diseaseIntramuscular benzathine penicillinIntravenous penicillinLate complicationsAntibiotic therapyArthritis patientsBenzathine penicillinMotor deficitsNeurologic abnormalitiesLate diseaseLate symptomsPatientsPhenoxymethyl penicillinAntibiotic agentsComplete recoveryDiseasePenicillin GArthritis
1985
Successful Parenteral Penicillin Therapy of Established Lyme Arthritis
Steere A, Green J, Schoen R, Taylor E, Hutchinson G, Rahn D, Malawista S. Successful Parenteral Penicillin Therapy of Established Lyme Arthritis. New England Journal Of Medicine 1985, 312: 869-874. PMID: 3883177, DOI: 10.1056/nejm198504043121401.Peer-Reviewed Original ResearchConceptsLyme arthritisComplete resolutionDouble-blind placebo-controlled trialAttacks of arthritisIntravenous penicillin GParenteral penicillin therapyPlacebo-controlled trialPenicillin-treated patientsErythema chronicum migransMean followPenicillin therapyParenteral therapyParenteral penicillinIntraarticular corticosteroidsJoint fluidArthritisPatientsLyme spirocheteFurther experienceTherapyPenicillin GOptimal courseDaysCorticosteroidsPlacebo
1984
The clinical spectrum and treatment of Lyme disease.
Steere A, Malawista S, Bartenhagen N, Spieler P, Newman J, Rahn D, Hutchinson G, Green J, Snydman D, Taylor E. The clinical spectrum and treatment of Lyme disease. The Yale Journal Of Biology And Medicine 1984, 57: 453-61. PMID: 6516448, PMCID: PMC2590003.Peer-Reviewed Original ResearchConceptsLyme diseaseHigh-dose intravenous penicillinJuvenile rheumatoid arthritisEarly Lyme diseaseErosion of cartilageErythema chronicum migransB-cell alloantigensIntravenous penicillinRheumatoid arthritisClinical spectrumProlonged illnessMultisystem disorderCardiac abnormalitiesIntermittent attacksEffective drugsPatientsDiseaseArthritisIllnessWeeksPenicillinSeparate entitiesGeographic clusteringAlloantigensLater stages