Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders
Hoehn-Saric R, Schlaepfer T, Greenberg B, McLeod D, Pearlson G, Wong S. Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research 2001, 108: 89-100. PMID: 11738543, DOI: 10.1016/s0925-4927(01)00114-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Flow VelocityCerebral CortexDepressive Disorder, MajorDesipramineDominance, CerebralDouble-Blind MethodFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedObsessive-Compulsive DisorderRegional Blood FlowSertralineTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsRegional cerebral blood flowHigher regional cerebral blood flowWeeks of treatmentCerebral blood flowYale-Brown Obsessive Compulsive ScaleBlood flowTemporal regionsType of medicationEffects of sertralineMajor depressive episodePrefrontal regional cerebral blood flowAdministration of medicationsPrefrontal regionsHMPAO SPECT scansEffect of treatmentObsessive Compulsive ScaleDiffuse reductionRCBF reductionStudy entryBasal gangliaDepressive episodeClinical changesMajor depressionDrug treatmentTreatment responders