1997
Quantification of Neuroreceptors in the Living Human Brain
Wong *, Pearlson ‡, Tune ‡, Young *, Meltzer *, Dannals *, Ravert *, Reith *, Kuhar †, Gjedde ¶. Quantification of Neuroreceptors in the Living Human Brain. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatients
1996
Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects
Tune L, Barta P, Wong D, Powers R, Pearlson G, Tien A, Wagner H. Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects. Psychiatry Research 1996, 67: 155-158. PMID: 8876015, DOI: 10.1016/0925-4927(96)02728-x.Peer-Reviewed Original ResearchConceptsSuperior temporal gyral volumeSuperior temporal gyrusPositron emission tomographyGyral volumeTemporal gyrusNormal groupSchizophrenic groupStriatal D2 receptor densityChronic schizophrenic subjectsRight superior temporal gyrusD2 receptor densityDopamine D2 receptorsStructural neuroimaging techniquesControl subjectsD2 receptorsReceptor densityNormal subjectsPET scansResonance imagingEmission tomographySchizophrenic subjectsBmax valuesNeuroimaging techniquesGyrusReceptor quantification
1993
Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone
Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, Dannals R, Wilson A, Ravert H, Sapp J, Cooper T, Chase G, Wagner H. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone. Psychiatry Research 1993, 49: 219-237. PMID: 7909948, DOI: 10.1016/0165-1781(93)90063-m.Peer-Reviewed Original ResearchConceptsPositron emission tomographySchizophrenic patientsBmax valuesEntire groupControl subjectsEmission tomographyDopamine D2 receptor densityNeuroleptic-free patientsDuration of illnessChronic schizophrenic patientsD2 receptor densityClinical characteristicsPatient populationReceptor abnormalitiesCorpus striatumClinical dataReceptor densityPatientsControl groupFunction of ageLate manifestationDifferent radioligandsFour-compartment modelSignificant differencesRadioligand
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntipsychotic AgentsCaudate NucleusHaloperidolHumansKineticsReceptors, DopamineReceptors, Dopamine D2SchizophreniaSpiperoneTomography, Emission-ComputedConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup