1996
Schizophrenia: A Disease of Heteromodal Association Cortex?
Pearlson G, Petty R, Ross C, Tien A. Schizophrenia: A Disease of Heteromodal Association Cortex? Neuropsychopharmacology 1996, 14: 1-17. PMID: 8719025, DOI: 10.1016/s0893-133x(96)80054-6.Peer-Reviewed Original ResearchConceptsHeteromodal association cortexAssociation cortexLocal gray matter volumeMultiple brain areasGray matter volumeNeuro-imaging studiesNeuropathologic examinationClinical featuresCortical abnormalitiesPrimary involvementBrain areasMatter volumeCortexDiseaseSchizophreniaConsiderable evidenceMagnetic resonanceFindings formNetwork of circuitsLesionsNeocortexAbnormalities
1994
Computed Tomography
Burns A, Pearlson G. Computed Tomography. 1994, 407-426. DOI: 10.1007/978-1-4615-6805-6_23.Peer-Reviewed Original ResearchComputed tomographyCerebral angiographyCerebrovascular accidentHead injuryNon-invasive methodBrain damageIntracerebral lesionsBrain tumorsFirst non-invasive methodClinical practiceClinical neuroscienceIntracranial structuresDementiaTomographyAngiographyInjuryLesionsPneumoencephalographyTumorsDiagnosis
1987
Mania After Brain Injury: A Controlled Study of Causative Factors
Starkstein S, Pearlson G, Boston J, Robinson R. Mania After Brain Injury: A Controlled Study of Causative Factors. JAMA Neurology 1987, 44: 1069-1073. PMID: 3632381, DOI: 10.1001/archneur.1987.00520220065019.Peer-Reviewed Original ResearchConceptsBrain injuryVentricle/brain ratiosPossible family historyFocal brain injurySecondary maniaRight hemisphere lesionsSubcortical atrophyBrain ratioDepressive episodeLimbic areasManic patientsFamily historyManic syndromeFocal lesionsAffective disordersPatientsInjuryLesionsCausative factorsRare occurrenceHemisphere lesionsGenetic loadingRight hemisphereManiaRight hemisphere involvement
1986
Cold Water Stress Abolishes Hyperactivity Produced by Cortical Suction Lesions Without Altering Noradrenergic Depletion
Moran T, Zern K, Pearlson G, Kubos K, Robinson R. Cold Water Stress Abolishes Hyperactivity Produced by Cortical Suction Lesions Without Altering Noradrenergic Depletion. Behavioral Neuroscience 1986, 100: 422-426. PMID: 3730151, DOI: 10.1037/0735-7044.100.3.422.Peer-Reviewed Original ResearchConceptsSuction lesionsControl animalsSham-operated control animalsFirst postoperative weekWeekly intervalsDevelopment of hyperactivityCold water swimmingPostoperative periodNoradrenergic depletionNorepinephrine depletionPostoperative weekCatecholamine depletionBehavioral hyperactivitySwim testLesion groupLesionsHyperactivityWeekly stress
1984
Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat
Pearlson G, Kubos K, Robinson R. Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat. Brain Research 1984, 293: 241-250. PMID: 6697218, DOI: 10.1016/0006-8993(84)91231-9.Peer-Reviewed Original ResearchConceptsSuction ablationLesion locationRight hemisphereConcentrations of norepinephrineContralateral cortexCortical lesionsAnterior lesionsLocus coeruleusSpontaneous activityNeurotransmitter pathwaysLocomotor activityGreater reductionLesionsRatsCortexBehavioral findingsBiochemical responsesAblationAnalysis of varianceAnterior-posterior axisNorepinephrineCoeruleusHyperactivityHemisphere
1983
Mood Change following Bilateral Hemisphere Brain Injury
Lipsey J, Robinson R, Pearlson G, Rao K, Price T. Mood Change following Bilateral Hemisphere Brain Injury. The British Journal Of Psychiatry 1983, 143: 266-273. PMID: 6626839, DOI: 10.1192/bjp.143.3.266.Peer-Reviewed Original ResearchConceptsHemisphere brain injuryFunctional physical impairmentBrain injuryCognitive impairmentPhysical impairmentLeft frontal lobe lesionFrontal lobe lesionsThromboembolic strokeBrain lesionsSuch injuriesCT scanLesion locationDepression severityLobe lesionsLesion proximityDepressive symptomatologyLesion ageFrontal poleInjuryMood changesPatientsImpairmentMood ScaleLesionsDepression
1982
Intracortical kainic acid induces an assymmetrical behavioral response in the rat
Kubos K, Pearlson G, Robinson R. Intracortical kainic acid induces an assymmetrical behavioral response in the rat. Brain Research 1982, 239: 303-309. PMID: 7093686, DOI: 10.1016/0006-8993(82)90857-5.Peer-Reviewed Original ResearchConceptsKainic acidCortical noradrenergic terminalsDay postoperative periodRight frontal cortexNoradrenergic terminalsPostoperative periodRight hemisphere lesionsSpontaneous hyperactivityFrontal cortexIdentical injectionsHemisphere lesionsNanomolar dosesLeft hemisphereHyperactivityRatsNeural asymmetriesInjectionBehavioral responsesPrevious studiesLesionsCortexDosesWeeks
1981
Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses
Pearlson G, Robinson R. Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses. Brain Research 1981, 218: 233-242. PMID: 7196790, DOI: 10.1016/0006-8993(81)91303-2.Peer-Reviewed Original ResearchConceptsFrontal cerebral cortexSuction lesionsCerebral cortexNorepinephrine concentrationsMiddle cerebral artery ligationContralateral cortexArtery ligationCatecholaminergic responseBilateral decreaseRats inducesLocus coeruleusSpontaneous hyperactivityWheel activityIdentical lesionsLesionsCortexObservation periodHyperactivityBiochemical asymmetriesCoeruleusRatsWeeks