2024
Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study
Rychagov N, Del Re E, Zeng V, Oykhman E, Lizano P, McDowell J, Yassin W, Clementz B, Gershon E, Pearlson G, Sweeney J, Tamminga C, Keshavan M. Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study. Schizophrenia Research 2024, 271: 169-178. PMID: 39032429, PMCID: PMC11384321, DOI: 10.1016/j.schres.2024.07.009.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkPsychotic disordersDSM-IVIntermediate Phenotypes studyGyrification changesSchizophrenia compared to controlsBipolar I disorderRight cingulate cortexSchizoaffective disorder probandsBipolar disorder probandsDisorders compared to controlsAge-related differencesSchizoaffective disorderCingulate cortexVerbal memoryBipolar disorderAge-related changesFalse discovery rate correctionSchizophreniaCortical gyrificationHypogyriaFrontal lobeGyrificationDisordersHealthy controlsRelating depressive and manic symptomatology to 1H-MRS spectra
Choquette A, Dager A, Marjańska M, Zatony M, Pearlson G, Glahn D, Knowles E. Relating depressive and manic symptomatology to 1H-MRS spectra. Journal Of Affective Disorders Reports 2024, 16: 100774. DOI: 10.1016/j.jadr.2024.100774.Peer-Reviewed Original ResearchAnterior cingulate cortexN-acetylaspartateRight anterior cingulate cortexAssociated with maniaDepressive symptom scalesSymptom Rating ScaleProfiles of associationDisorder symptomatologyManic symptomsReduced N-acetylaspartateCingulate cortexAffective disordersNeurochemical levelsSymptom ScaleManiaCholine-containing compoundsDichotomous diagnosisMagnetic resonance spectroscopyRating ScalePotential in vivo biomarkersHippocampusIllness etiologyMagnetic resonance spectroscopy dataTotal cholineFollow-up
2022
Acute cannabis-related alterations in an fMRI time estimation task
Patel K, Stevens M, Adhikari S, Book G, Mubeen M, Pearlson G. Acute cannabis-related alterations in an fMRI time estimation task. 2022 DOI: 10.26828/cannabis.2022.02.000.26.Peer-Reviewed Original ResearchMedial temporal cortexPosterior cingulate cortexSomatosensory motor cortexPremotor cortexMotor cortexTemporal cortexMedial prefrontal cortexCingulate cortexFrontal cortexLong-duration stimuliAnterior cingulateInferior frontal cortexVisual cortexBrain activation differencesMultiple comparison correctionPlacebo conditionActivation differencesDuration stimuliPrefrontal cortexVisual areasOccipital junctionDose-related mannerMid-cingulate cortexSignificant activation differencesPopular recreational drug