Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromiseBiosynthesis of proresolving lipid mediators by vascular cells and tissues
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. The FASEB Journal 2017, 31: 3393-3402. PMID: 28442547, PMCID: PMC6207217, DOI: 10.1096/fj.201700082r.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesArachidonate 5-LipoxygenaseCells, CulturedCytokinesDocosahexaenoic AcidsEndothelial CellsGene Expression RegulationHumansInflammationLeukocytesLipid MetabolismMolecular StructureMyocytes, Smooth MuscleProtein TransportReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, LipoxinConceptsVascular smooth muscle cellsD-series resolvinsLipid mediatorsDocosahexaenoic acidVascular cellsEndothelial cellsRvD1 receptor ALX/FPR2Receptor ALX/FPR2Proresolving lipid mediatorsALX/FPR2Vascular injury responseHuman arteriesSmooth muscle cellsHuman saphenous vein endothelial cellsSaphenous vein endothelial cellsIntact human arteriesVein endothelial cellsResolvin D1Vascular healthNovel homeostatic mechanismCellular sourceInjury responseMonocyte adhesionMuscle cellsLiquid chromatography-tandem mass spectrometry