Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1
Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, Mckanna JA, Harris RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1. Kidney International 2002, 62: 929-939. PMID: 12164875, DOI: 10.1046/j.1523-1755.2002.00520.x.Peer-Reviewed Original ResearchConceptsCOX-2 expressionCOX-2 inhibitorsDiabetic groupRenal injuryDiabetic ratsImmunoreactive COX-2 expressionCortical thick ascending limbSelective COX-2 inhibitorsSystolic blood pressureModel of diabetesVascular endothelial growth factorDevelopment of glomerulosclerosisCOX-2 inhibitionThick ascending limbEndothelial growth factorMesangial sclerosis indexTubulointerstitial injuryDiabetic nephropathyBlood pressureChronic treatmentSubtotal nephrectomySclerosis indexBlood glucoseMacula densaRenal cortex