2020
Polycystin 2 is increased in disease to protect against stress-induced cell death
Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.Peer-Reviewed Original ResearchConceptsPolycystin-2General cellular homeostasisCell deathStress-induced cell deathPathological cell deathAutosomal dominant polycystic kidney diseaseEndoplasmic reticulum membraneCellular homeostasisCellular stressPrimary ciliaUbiquitous expressionExpression changesCell stressReticulum membraneTransient receptor potential cation channelHuman diseasesMultiple tissuesEndogenous roleDominant polycystic kidney diseaseTissue typesCation channelsPolycystic kidney diseaseDifferent pathological statesMultiple diseasesKidney disease
2011
SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function
Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function. Diabetes 2011, 60: 890-898. PMID: 21357472, PMCID: PMC3046850, DOI: 10.2337/db10-1328.Peer-Reviewed Original ResearchConceptsHigh-fat dietPancreatic β-cell functionΒ-cell functionDb/db backgroundKnockout miceGlucose intoleranceGlucose homeostasisPreserves pancreatic β-cell functionDb/db miceImproved glucose intoleranceGlucose-stimulated insulin secretionRenal glucose excretionPrevention of hyperglycemiaRenal glucose reabsorptionType 2 diabetesDb backgroundPlasma insulin concentrationCotransporter type 2Β-cell massObesity-associated hyperglycemiaΒ-cell deathRegular chowGlucose excretionUrine outputSGLT2 inhibition