2012
Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome.
Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Clinical Nephrology 2012, 77: 62-5. PMID: 22185970, DOI: 10.5414/cn106859.Peer-Reviewed Original ResearchMeSH KeywordsGlomerulosclerosis, Focal SegmentalHumansKidneyMaleMiddle AgedObesity Hypoventilation SyndromeObesity, MorbidPositive-Pressure RespirationProteinuriaTreatment OutcomeConceptsObstructive sleep apneaFocal segmental glomerulosclerosisSleep apneaSegmental glomerulosclerosisBi-level positive airway pressureSecondary focal segmental glomerulosclerosisObesity hypoventilation syndromePositive airway pressureResolution of proteinuriaPatient's proteinuriaGlomerular hyperfiltrationAirway pressureSevere obesityHypoventilation syndromeHeavy proteinuriaComplete resolutionProteinuriaGlomerulosclerosisApneaObesityPatientsTreatmentHyperfiltrationSyndrome
2005
Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition
Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC. Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition. Nephron 2005, 101: e75-e85. PMID: 15995341, DOI: 10.1159/000086645.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConnective Tissue Growth FactorCyclooxygenase 2 InhibitorsFibronectinsGlomerulosclerosis, Focal SegmentalImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsKidneyKidney TubulesMiceMice, Inbred StrainsNephrectomyProteinuriaProto-Oncogene Proteins c-metPyrazolesSulfonamidesTissue DistributionConceptsCyclooxygenase-2 inhibitionROP miceSC58236 treatmentRenal injuryRemnant kidneyImmunoreactive COX-2Immunoreactive TGF-beta1Selective COX-2 inhibitorsSystemic blood pressureConnective tissue growth factorSubtotal renal ablationRenal tubulointerstitial injuryExpression of mediatorsCOX-2 inhibitorsTissue growth factorCollagen IV mRNATubulointerstitial injuryBlood pressureRenal ablationSignificant albuminuriaCOX-2Macrophage markersMouse modelTGF-beta1Remnant group
2004
A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy
Fisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. American Journal Of Kidney Diseases 2004, 44: 567-573. PMID: 15332232, DOI: 10.1053/j.ajkd.2004.04.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAntiviral AgentsBiopsyFemaleGlomerulosclerosis, Focal SegmentalHepatitis C, ChronicHumansInterferon-alphaMiddle AgedNephritis, InterstitialNephrotic SyndromeLack of Integrin α1β1 Leads to Severe Glomerulosclerosis after Glomerular Injury
Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of Integrin α1β1 Leads to Severe Glomerulosclerosis after Glomerular Injury. American Journal Of Pathology 2004, 165: 617-630. PMID: 15277235, PMCID: PMC1618576, DOI: 10.1016/s0002-9440(10)63326-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiotics, AntineoplasticAntioxidantsCell AdhesionCollagen Type IVDoxorubicinGlomerular MesangiumGlomerulosclerosis, Focal SegmentalHomozygoteIntegrin alpha1beta1MaleMiceMice, Inbred BALB CReactive Oxygen SpeciesConceptsSevere glomerulosclerosisGlomerular injuryIntegrin alpha1-null miceSeverity of fibrosisCollagen IV accumulationWild-type miceHost genetic susceptibilityMetabolism of collagenReactive oxygen species productionFibrotic lesionsIntegrin alpha1beta1Oxygen species productionAdriamycin treatmentMesangial cellsMatrix accumulationGenetic susceptibilityInjuryGlomerulosclerosisFibrosisCell proliferationROS productionSpecies productionROS synthesisIntegrin α1β1Mice