2016
Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial
Kulkarni S, Kirkiles‐Smith N, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation 2016, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedChronic DiseaseComplement C5Complement Inactivating AgentsEarly Intervention, EducationalFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHumansIsoantibodiesKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedPilot ProjectsPrognosisRisk FactorsTissue DonorsTransplant RecipientsYoung AdultConceptsDe novo donor-specific antibodiesComplement inhibitionTreatment groupsNovo donor-specific antibodiesAntibody-Mediated InjuryC1q-positive patientsDonor-specific antibodiesKidney transplant recipientsPrimary end pointEndothelial cell injuryMo of observationEculizumab therapyEculizumab treatmentHumoral injuryTransplant recipientsKidney transplantRenal functionKidney functionChronic settingEGFR trajectoriesTreatment periodCell injuryPatientsEnd pointPercentage change
2010
Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic Leukemia
Seo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic Leukemia. American Journal Of Kidney Diseases 2010, 56: 1001-1005. PMID: 20599308, DOI: 10.1053/j.ajkd.2010.03.029.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaKidney biopsy specimenKidney functionLymphoblastic leukemiaAcute B-cell lymphoblastic leukemiaSmall round blue cellsB-cell lymphoblastic leukemiaInitial presenting signRound blue cellsExtensive retroperitoneal lymphadenopathySignificant nuclear atypiaInduction chemotherapyInitial manifestationRetroperitoneal lymphadenopathyBilateral nephromegalyPresenting signImmunohistochemical workupInterstitial infiltratesBiopsy specimenNuclear atypiaComputed tomographyPositive stainingUnusual caseTerminal deoxynucleotidyl transferaseInitial signs