2009
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity
Kwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflügers Archiv - European Journal Of Physiology 2009, 459: 183. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.Peer-Reviewed Original ResearchConceptsCellular adaptationRegulation of TonEBPBody water homeostasisAmbient tonicityEpithelial cell lineCentral regulatorMDCK cellsTonEBPCellular proliferationWater homeostasisCell linesExpressionPrior adaptationInner medullaAdaptationRenal medullaAntidiuretic animalsHypertonicityRegulatorHomeostasisRegulationHigh levelsProliferationCellsModerate changes
2003
COX2 Activity Promotes Organic Osmolyte Accumulation and Adaptation of Renal Medullary Interstitial Cells to Hypertonic Stress*
Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 Activity Promotes Organic Osmolyte Accumulation and Adaptation of Renal Medullary Interstitial Cells to Hypertonic Stress*. Journal Of Biological Chemistry 2003, 278: 19352-19357. PMID: 12637551, DOI: 10.1074/jbc.m302209200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAldehyde ReductaseAnimalsApoptosisBetaineCaspase 3CaspasesCell SurvivalCells, CulturedCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDehydrationDNA FragmentationGene ExpressionHeat-Shock ProteinsHypertonic SolutionsIn Situ Nick-End LabelingInositolIsoenzymesKidney MedullaMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutProstaglandin-Endoperoxide SynthasesRNA, MessengerSorbitolSymportersTritiumConceptsMedullary interstitial cellsRenal medullary interstitial cellsInterstitial cellsCOX2 activityCOX2 inhibitionReductase mRNA expressionCOX2-specific inhibitorsRenal cell survivalCell survivalAnalgesic nephropathyCOX2 inhibitorsRenal medullaMRNA expressionPmol/Sorbitol accumulationInner medullaOrganic osmolyte accumulationKidney inner medullaMedullaCell deathBetaine concentrationsHypertonic stressPresent studySurvivalInhibitors
2002
Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases
Moeckel GW, Shadman R, Fogel JM, Sadrzadeh SM. Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases. Life Sciences 2002, 71: 2413-2424. PMID: 12231402, DOI: 10.1016/s0024-3205(02)02035-0.Peer-Reviewed Original Research
2000
Reabsorption of betaine in Henle's loops of rat kidney in vivo
Pummer S, Dantzler W, Lien Y, Moeckel G, Völker K, Silbernagl S. Reabsorption of betaine in Henle's loops of rat kidney in vivo. American Journal Of Physiology. Renal Physiology 2000, 278: f434-f439. PMID: 10710548, DOI: 10.1152/ajprenal.2000.278.3.f434.Peer-Reviewed Original Research
1997
Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation
Moeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. American Journal Of Physiology 1997, 272: f94-f99. PMID: 9039054, DOI: 10.1152/ajprenal.1997.272.1.f94.Peer-Reviewed Original ResearchConceptsRenal cortexMale Sprague-Dawley ratsSprague-Dawley ratsHepatic arteryRenal arteryRenal synthesisFurosemide diuresisPortal veinOxidase inhibitorsRat kidneyKidneyTotal urineMedullary concentrationUrine samplesMedullaMedullary cellsCortexArteryDe novo synthesisBetaine concentrationsMammalian kidneyWater deprivationDe novoMinNovo synthesisKinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla
Moeckel G, Lai L, Guder W, Kwon H, Lien Y. Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla. American Journal Of Physiology 1997, 272: f100-f106. PMID: 9039055, DOI: 10.1152/ajprenal.1997.272.1.f100.Peer-Reviewed Original Research
1994
Bicarbonate dependency of betaine synthesis in cultured LLC-PK1 cells
Moeckel G, Lien Y. Bicarbonate dependency of betaine synthesis in cultured LLC-PK1 cells. American Journal Of Physiology 1994, 266: f512-f515. PMID: 8160802, DOI: 10.1152/ajprenal.1994.266.3.f512.Peer-Reviewed Original ResearchBicarbonate-Dependent Betaine Synthesis in Rat Kidney1
Moeckel G, Dasser H, Chen T, Schmolke M, Guder W. Bicarbonate-Dependent Betaine Synthesis in Rat Kidney1. Contributions To Nephrology 1994, 110: 46-53. PMID: 7956256, DOI: 10.1159/000423397.Peer-Reviewed Original Research