2009
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity
Kwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflügers Archiv - European Journal Of Physiology 2009, 459: 183. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.Peer-Reviewed Original ResearchConceptsCellular adaptationRegulation of TonEBPBody water homeostasisAmbient tonicityEpithelial cell lineCentral regulatorMDCK cellsTonEBPCellular proliferationWater homeostasisCell linesExpressionPrior adaptationInner medullaAdaptationRenal medullaAntidiuretic animalsHypertonicityRegulatorHomeostasisRegulationHigh levelsProliferationCellsModerate changes
2003
Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress
Lamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. American Journal Of Physiology - Cell Physiology 2003, 286: c785-c791. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.Peer-Reviewed Original ResearchConceptsExtreme osmotic stressOsmotic stressCell osmoregulationHypertonic stressFunctional genomic analysisNematode Caenorhabditis elegansOrganic osmolyte glycerolPowerful model systemNumerous experimental advantagesCellular osmotic homeostasisCaenorhabditis elegansC. elegansCellular lifeNematode CaenorhabditisOsmolyte glycerolGenomic analysisOsmotic homeostasisGenetic basisOsmotic adaptationTranscriptional expressionOsmotic balanceMolecular understandingAccumulation of glycerolGlycerol accumulationNaCl agar
1997
Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation
Moeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. American Journal Of Physiology 1997, 272: f94-f99. PMID: 9039054, DOI: 10.1152/ajprenal.1997.272.1.f94.Peer-Reviewed Original ResearchConceptsRenal cortexMale Sprague-Dawley ratsSprague-Dawley ratsHepatic arteryRenal arteryRenal synthesisFurosemide diuresisPortal veinOxidase inhibitorsRat kidneyKidneyTotal urineMedullary concentrationUrine samplesMedullaMedullary cellsCortexArteryDe novo synthesisBetaine concentrationsMammalian kidneyWater deprivationDe novoMinNovo synthesisKinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla
Moeckel G, Lai L, Guder W, Kwon H, Lien Y. Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla. American Journal Of Physiology 1997, 272: f100-f106. PMID: 9039055, DOI: 10.1152/ajprenal.1997.272.1.f100.Peer-Reviewed Original Research