2014
Semaphorin3a Promotes Advanced Diabetic Nephropathy
Aggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. Semaphorin3a Promotes Advanced Diabetic Nephropathy. Diabetes 2014, 64: 1743-1759. PMID: 25475434, PMCID: PMC4407856, DOI: 10.2337/db14-0719.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsChromonesCollagen Type IVDiabetes Mellitus, ExperimentalDiabetic NephropathiesEnzyme-Linked Immunosorbent AssayGene Expression RegulationGene Knockdown TechniquesHumansIntegrin alphaVbeta3LamininMembrane ProteinsMiceMice, KnockoutMicrofilament ProteinsMicrotubule-Associated ProteinsMixed Function OxygenasesNerve Tissue ProteinsPodocytesProteinuriaReceptors, Cell SurfaceRenal InsufficiencySemaphorin-3AWT1 ProteinsXanthonesConceptsAdvanced diabetic nephropathyDiabetic nephropathyRenal insufficiencyDiffuse podocyte foot process effacementPodocyte foot process effacementSevere diabetic nephropathyCollagen IV accumulationPotential therapeutic targetFoot process effacementGlomerular nodulesKimmelstiel-WilsonRenal biopsyGlomerular filtration barrierNodular glomerulosclerosisDiabetic miceMassive proteinuriaNovel therapiesDisease outcomePathogenic factorsTargetable pathwaysTherapeutic targetProcess effacementBarrier abnormalitiesFunction miceNephropathyBile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic Steroid
Luciano RL, Castano E, Moeckel G, Perazella MA. Bile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic Steroid. American Journal Of Kidney Diseases 2014, 64: 473-476. PMID: 24953892, DOI: 10.1053/j.ajkd.2014.05.010.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injurySevere cholestatic liver diseaseCholestatic liver diseaseLiver diseaseAcute tubular injury/necrosisCases of AKIEnd-stage liver diseaseBile acid injurySevere obstructive jaundiceAcute tubular injuryAnabolic androgenic steroidsAnabolic-androgenic steroid useCholemic nephrosisHepatorenal syndromeKidney injuryTubular injuryObstructive jaundiceHemodynamic changesTubular toxicitySteroid useAcid injuryHepatic diseaseTubular cellsHeterogeneous lesionsNephropathy
2013
Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin
Moeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Clinical Kidney Journal 2013, 6: 507-509. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.Peer-Reviewed Case Reports and Technical NotesAcute kidney injuryTubular injuryIgA nephropathyMild IgA nephropathyAcute tubular injuryLong-term anticoagulationDirect thrombin inhibitorKidney injurySevere hematuriaRenal biopsyGlomerular pathologyDabigatranPatientsThrombin inhibitorsNephropathyInjuryWarfarinAnticoagulationHematuriaAspirinBiopsyPathologyNALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.Peer-Reviewed Original ResearchConceptsProgressive renal failureRenal failureCalcium oxalate crystal depositionCrystal-associated diseasesOverproduction of oxalateWild-type miceHigh-oxalate dietNephropathy resultsOxalate nephropathyRenal histologyKidney diseaseOxalate dietInflammatory responseNALP3 expressionDietary oxalateIntestinal oxalateOxalate homeostasisSoluble oxalateNephropathyCrystal depositionMiceMultiple disordersNALP3DietInflammation
2011
Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor Expression
Cheng H, Fan X, Moeckel GW, Harris RC. Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor Expression. Journal Of The American Society Of Nephrology 2011, 22: 1240-1251. PMID: 21737546, PMCID: PMC3137572, DOI: 10.1681/asn.2010111149.Peer-Reviewed Original ResearchConceptsCOX-2 transgenic miceDiabetic nephropathyFoot process effacementCOX-2Transgenic miceGlomerular injuryReceptor expressionHigh glucoseRenin-angiotensin systemMesangial matrix expansionCOX-2 inhibitionWild-type miceCOX-2 inhibitorsCyclooxygenase-2 expressionGlomerular basement membraneStreptozotocin modelProgressive albuminuriaSegmental thickeningMesangial expansionDiabetic mellitusCell injuryAnimal modelsInjuryIncreased expressionNephropathy